Abstract
Three new triterpene glycosides, bacopasides VI-VIII (1-3), together with three known analogues, bacopaside I (4), bacopaside II (5), and bacopasaponsin C (6), were isolated from the whole plant of Bacopa monnieri. Compounds 4, 5, and 6 showed antidepressant activity when tested on forced swimming and tail suspension in mice, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidepressive Agents* / chemistry
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Antidepressive Agents* / isolation & purification
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Antidepressive Agents* / pharmacology
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Bacopa / chemistry*
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Drugs, Chinese Herbal* / chemistry
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Drugs, Chinese Herbal* / isolation & purification
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Drugs, Chinese Herbal* / pharmacology
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Mice
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Models, Animal*
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Plants, Medicinal / chemistry*
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Saponins* / chemistry
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Saponins* / isolation & purification
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Saponins* / pharmacology
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Triterpenes* / chemistry
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Triterpenes* / isolation & purification
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Triterpenes* / pharmacology
Substances
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Antidepressive Agents
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Drugs, Chinese Herbal
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Saponins
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Triterpenes
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bacopaside VI
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bacopaside VII
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bacopaside VIII