The structure activity relationship of discodermolide analogues

Mini Rev Med Chem. 2008 Mar;8(3):276-84. doi: 10.2174/138955708783744137.

Abstract

The marine polyketide discodermolide is a member of a class of natural products that stabilize microtubules. Many analogues have been synthesized suggesting that few changes can be made to the internal carbon backbone. Both ends of the molecule, however, can be modified. The majority of analogues have been generated via modification of the lactone region. This suggests that significant simplifications can be made in this region provided that the lactone moiety is maintained.

Publication types

  • Review

MeSH terms

  • Alkanes / chemical synthesis
  • Alkanes / chemistry*
  • Alkanes / pharmacology*
  • Alkanes / toxicity
  • Animals
  • Carbamates / chemical synthesis
  • Carbamates / chemistry*
  • Carbamates / pharmacology*
  • Carbamates / toxicity
  • Humans
  • Lactones / chemical synthesis
  • Lactones / chemistry*
  • Lactones / pharmacology*
  • Lactones / toxicity
  • Macrolides / chemistry
  • Pyrones / chemical synthesis
  • Pyrones / chemistry*
  • Pyrones / pharmacology*
  • Pyrones / toxicity
  • Structure-Activity Relationship

Substances

  • Alkanes
  • Carbamates
  • Lactones
  • Macrolides
  • Pyrones
  • dictyostatin
  • discodermolide