Abstract
The neuronal GABAergic mechanisms that mediate the symptomatic beneficial effects elicited by a combination of antipsychotics with valproate (a histone deacetylase inhibitor) in the treatment of psychosis (expressed by schizophrenia or bipolar disorder patients) are unknown. This prompted us to investigate whether the beneficial action of this combination results from a modification of histone tail covalent esterification or is secondary to specific chromatin remodeling. The results suggest that clozapine, or sulpiride associated with valproate, by increasing DNA demethylation with an unknown mechanism, causes a chromatin remodeling that brings about a beneficial change in the epigenetic GABAergic dysfunction typical of schizophrenia and bipolar disorder patients.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Antipsychotic Agents / pharmacology
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Brain / drug effects
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Brain / metabolism
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Cell Adhesion Molecules, Neuronal / genetics
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DNA Methylation / genetics*
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Epigenesis, Genetic*
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Extracellular Matrix Proteins / genetics
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Gene Expression Regulation
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Genetic Predisposition to Disease
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Glutamate Decarboxylase / genetics
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Humans
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Nerve Tissue Proteins / genetics
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Neurons / drug effects
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Neurons / metabolism
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Promoter Regions, Genetic / genetics*
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Reelin Protein
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Schizophrenia / drug therapy
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Schizophrenia / genetics*
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Serine Endopeptidases / genetics
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gamma-Aminobutyric Acid / metabolism*
Substances
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Antipsychotic Agents
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Cell Adhesion Molecules, Neuronal
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Extracellular Matrix Proteins
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Nerve Tissue Proteins
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Reelin Protein
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gamma-Aminobutyric Acid
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Serine Endopeptidases
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Glutamate Decarboxylase
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glutamate decarboxylase 1