Trichogin GA IV: an antibacterial and protease-resistant peptide

Marta De Zotti; Barbara Biondi; Fernando Formaggio; Claudio Toniolo; Lorenzo Stella; Yoonkyung Park; Kyung-Soo Hahm

doi:10.1002/psc.1135

Trichogin GA IV: an antibacterial and protease-resistant peptide

J Pept Sci. 2009 Sep;15(9):615-9. doi: 10.1002/psc.1135.

Authors

Marta De Zotti¹, Barbara Biondi, Fernando Formaggio, Claudio Toniolo, Lorenzo Stella, Yoonkyung Park, Kyung-Soo Hahm

Affiliation

¹ Institute of Biomolecular Chemistry, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova, Italy.

PMID: 19399781
DOI: 10.1002/psc.1135

Abstract

The antibacterial and hemolytic activities of the amphiphilic helical, membrane-active, lipopeptaibol trichogin GA IV and its [Leu(11)-OMe] analogue were compared to those of the partially helical or non-helical 8-meric or 4-meric, C-terminal short sequences, respectively. The study on trichogin GA IV was extended to several methicillin-resistant Staphylococcus aureus strains. Using a large set of enzymes, we also evaluated the resistance to proteolysis of all of the four peptides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimicrobial Cationic Peptides / chemical synthesis
Antimicrobial Cationic Peptides / chemistry
Antimicrobial Cationic Peptides / metabolism*
Antimicrobial Cationic Peptides / pharmacology*
Bacteria / drug effects*
Candida albicans / drug effects
Chromatography, High Pressure Liquid
Circular Dichroism
Hemolysis / drug effects
Lipopeptides / chemistry
Lipopeptides / metabolism
Lipopeptides / pharmacology*
Microbial Sensitivity Tests
Peptide Hydrolases / metabolism*

Substances

Antimicrobial Cationic Peptides
Lipopeptides
trichogin GA IV
Peptide Hydrolases