Regulator of G-protein signaling (RGS) proteins in cancer biology

Jillian H Hurst; Shelley B Hooks

doi:10.1016/j.bcp.2009.06.028

Regulator of G-protein signaling (RGS) proteins in cancer biology

Biochem Pharmacol. 2009 Nov 15;78(10):1289-97. doi: 10.1016/j.bcp.2009.06.028. Epub 2009 Jun 25.

Authors

Jillian H Hurst¹, Shelley B Hooks

Affiliation

¹ Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.

PMID: 19559677
DOI: 10.1016/j.bcp.2009.06.028

Abstract

The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types.

Publication types

Review

MeSH terms

Animals
Guanine Nucleotide Exchange Factors / biosynthesis
Guanine Nucleotide Exchange Factors / genetics
Guanine Nucleotide Exchange Factors / physiology
Humans
Neoplasms / genetics
Neoplasms / metabolism*
Polymorphism, Single Nucleotide
RGS Proteins* / biosynthesis
RGS Proteins* / genetics
RGS Proteins* / physiology
Receptors, G-Protein-Coupled / biosynthesis
Receptors, G-Protein-Coupled / genetics
Receptors, G-Protein-Coupled / physiology
Rho Guanine Nucleotide Exchange Factors
Signal Transduction

Substances

Guanine Nucleotide Exchange Factors
RGS Proteins
Receptors, G-Protein-Coupled
Rho Guanine Nucleotide Exchange Factors