Successful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy

F Ward; O Dunne; T B Crotty; D Fennelly; A Watson; J Holian

Successful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy

Ir Med J. 2012 May;105(5):148-9.

Authors

F Ward¹, O Dunne, T B Crotty, D Fennelly, A Watson, J Holian

Affiliation

¹ Department of Nephrology, St Vincent's University Hospital, Dublin 4. fward79@hotmail.com

PMID: 22803494

Abstract

We present the case of a 58-year old female with de novo dialysis-dependent acute kidney injury (AKI) secondary to myeloma cast nephropathy. The patient underwent extended high cut-off haemodialysis (HCO-HD), in conjunction with bortezomib-based chemotherapy, and soon became dialysis independent with normal renal function. To our knowledge, this is the first time this treatment strategy has been employed successfully in an Irish centre.

Publication types

Case Reports

MeSH terms

Acute Kidney Injury / blood
Acute Kidney Injury / etiology
Acute Kidney Injury / therapy*
Anti-Bacterial Agents / therapeutic use
Antineoplastic Agents / therapeutic use*
Biopsy
Boronic Acids / therapeutic use*
Bortezomib
Combined Modality Therapy
Female
Humans
Ireland
Kidney Function Tests
Middle Aged
Multiple Myeloma / complications*
Multiple Myeloma / drug therapy
Pyrazines / therapeutic use*
Renal Dialysis / methods*

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Boronic Acids
Pyrazines
Bortezomib