CCR7: roles in cancer cell dissemination, migration and metastasis formation

Daniel F Legler; Edith Uetz-von Allmen; Mark A Hauser

doi:10.1016/j.biocel.2014.07.002

CCR7: roles in cancer cell dissemination, migration and metastasis formation

Int J Biochem Cell Biol. 2014 Sep:54:78-82. doi: 10.1016/j.biocel.2014.07.002. Epub 2014 Jul 11.

Authors

Daniel F Legler¹, Edith Uetz-von Allmen², Mark A Hauser²

Affiliations

¹ Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland. Electronic address: daniel.legler@bitg.ch.
² Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.

PMID: 25019368
DOI: 10.1016/j.biocel.2014.07.002

Abstract

The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.

Keywords: Cancer; Cell migration; Chemokine receptor; Lymph node homing; Metastasis formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Movement*
Chemotaxis
Humans
Lymphatic Metastasis
Neoplasms / metabolism*
Neoplasms / pathology*
Receptors, CCR7 / metabolism*

Substances

Receptors, CCR7

Grants and funding

143841/SNSF_/Swiss National Science Foundation/Switzerland