The role of inhibition in human motor cortical plasticity

Neuroscience. 2014 Oct 10:278:93-104. doi: 10.1016/j.neuroscience.2014.07.059. Epub 2014 Aug 1.

Abstract

Over recent years evidence from animal studies strongly suggests that a decrease in local inhibitory signaling is necessary for synaptic plasticity to occur. However, the role of GABAergic modulation in human motor plasticity is less well understood. Here, we summarize the techniques available to quantify GABA in humans, before reviewing the existing evidence for the role of inhibitory signaling in human motor plasticity. We discuss a number of important outstanding questions that remain before the role of GABAergic modulation in long-term plasticity in humans, such as that underpinning recovery after stroke, can be established.

Keywords: GABA; human; motor; plasticity; stroke recovery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / physiology
  • Humans
  • Learning / physiology
  • Motor Activity
  • Motor Cortex / physiology*
  • Neural Inhibition*
  • Neuronal Plasticity*
  • Recovery of Function
  • Stroke / physiopathology*
  • gamma-Aminobutyric Acid / analysis
  • gamma-Aminobutyric Acid / physiology*

Substances

  • gamma-Aminobutyric Acid