Abstract
Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is one of the most common events in human cancers. In this Review, we discuss recent advances in our knowledge of the roles of specific PI3K isoforms in normal and oncogenic signalling, the different ways in which PI3K can be upregulated, and the current state and future potential of targeting this pathway in the clinic.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Drug Resistance, Neoplasm
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Humans
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / physiology
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Molecular Targeted Therapy
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Neoplasms / drug therapy
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Neoplasms / enzymology*
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Phosphatidylinositol 3-Kinases / physiology*
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Phosphatidylinositol Phosphates / metabolism
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Phosphoinositide-3 Kinase Inhibitors
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Signal Transduction
Substances
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Antineoplastic Agents
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Isoenzymes
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Phosphatidylinositol Phosphates
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Phosphoinositide-3 Kinase Inhibitors