Abstract
Interaction effects of cannabidiol (CBD) and cannabinol (CBN) were examined using a drug discrimination procedure in which rats had been trained to discriminate between 3 mg/kg of delta 9-tetrahydrocannabinol (delta 9-THC) and vehicle (2 ml/kg). The generalization effects of CBN to delta 9-THC were attenuated when CBN was administered together with CBD. The results were time- and dose-dependent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cannabidiol / pharmacology*
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Cannabinoids / pharmacology*
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Cannabinol / pharmacology*
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Discrimination, Psychological / drug effects*
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Dose-Response Relationship, Drug
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Dronabinol / pharmacology*
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Drug Interactions
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Generalization, Stimulus / drug effects
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Male
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Rats
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Rats, Inbred Strains
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Time Factors
Substances
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Cannabinoids
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Cannabidiol
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Dronabinol
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Cannabinol