Abstract
Specific binding of one of the most potent analogs of phencyclidine (PCP), [3H]PCP-3-OH, in rat brain membranes revealed the labeling of high (Kd = 0.5 nM) and low (Kd = 16 nM) affinity binding sites. (+)SKF 10047 potently inhibited high, but not low, affinity [3H]PCP-3-OH binding. (+)[3H]SKF 10047 apparently labeled the high affinity PCP-3-OH binding site and also an additional site, sensitive to haloperidol, which is distinct from the two sites labeled by [3H]PCP-3-OH.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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Binding, Competitive / drug effects
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Brain / metabolism*
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Haloperidol / pharmacology
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In Vitro Techniques
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Phenazocine / analogs & derivatives*
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Phenazocine / metabolism
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Phencyclidine / analogs & derivatives*
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Phencyclidine / metabolism
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Rats
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Receptors, Neurotransmitter / metabolism*
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Receptors, Phencyclidine
Substances
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Receptors, Neurotransmitter
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Receptors, Phencyclidine
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SK&F 10047
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3-hydroxyphencyclidine
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Phenazocine
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Phencyclidine
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Haloperidol