Abstract
We have cloned and sequenced cDNAs of the strychnine-binding subunit of the rat glycine receptor, a neurotransmitter-gated chloride channel protein of the CNS. The deduced polypeptide shows significant structural and amino-acid sequence homology with nicotinic acetylcholine receptor proteins, indicating that there is a family of genes encoding neurotransmitter-gated ion channels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Cloning, Molecular
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DNA / genetics
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Membrane Proteins / genetics*
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Multigene Family
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Protein Binding
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Protein Conformation
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Rats
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Receptors, Glycine
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Receptors, Neurotransmitter / genetics*
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Receptors, Nicotinic / genetics*
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Sequence Homology, Nucleic Acid
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Strychnine / metabolism*
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Tissue Distribution
Substances
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Membrane Proteins
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Receptors, Glycine
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Receptors, Neurotransmitter
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Receptors, Nicotinic
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DNA
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Strychnine