Abstract
The hepatoprotective activity against CCl4 toxicity in isolated rat hepatocytes of some polyphenolic compounds, such as cynarin, isochlorogenic acid, chlorogenic acid, luteolin-7-glucoside, and two organic acids, caffeic and quinic, from Cynara scolymus, is tested. Only cynarine and, to a lesser extent, caffeic acid showed cytoprotective action. The possible relationship between the molecular structure and the protective effect found is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Animals
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Aspartate Aminotransferases / blood
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Carbon Tetrachloride Poisoning / prevention & control*
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Cell Survival / drug effects
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Chemical and Drug Induced Liver Injury / prevention & control*
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Flavonoids*
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Liver / drug effects
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Liver / pathology
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Male
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Phenols / isolation & purification*
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Phenols / therapeutic use
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Plants, Medicinal / analysis*
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Polymers / isolation & purification*
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Polymers / therapeutic use
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Polyphenols
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Rats
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Rats, Inbred Strains
Substances
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Flavonoids
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Phenols
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Polymers
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Polyphenols
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Aspartate Aminotransferases
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Alanine Transaminase