Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma

Oncogene. 1995 Sep 7;11(5):999-1003.

Abstract

Recent studies have implicated a role for the p50 subunit of the NF-kappa B transcription factor complex in tumorigenesis. Therefore, we investigated the expression of the p50 subunit of the NF-kappa B transcription factor complex in paired normal and non-small cell lung carcinoma (NSCLC) tissues. Here we show that nine of 11 (81.8%) fresh NSCLC tissues expressed from two- to 20-fold higher levels of the p50 subunit than normal lung tissue. Thirteen NSCLC cell lines also exhibited high levels of p50. Alterations in the normal NF-kappa B/rel pathway of regulation may play a role in the genesis of NSCLC.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / metabolism*
  • Humans
  • Lung Neoplasms / metabolism*
  • NF-kappa B / biosynthesis*
  • NF-kappa B / genetics
  • NF-kappa B p50 Subunit
  • RNA, Messenger / analysis
  • Tumor Cells, Cultured

Substances

  • NF-kappa B
  • NF-kappa B p50 Subunit
  • RNA, Messenger