Abstract
The effects of chlorpromazine on either the activity of mouse brain nitric oxide synthase or the induction of lung nitric oxide synthase in mice and rats were studied. Chlorpromazine inhibited the nitric oxide synthase activity in mouse brain cytosol. This effect could be reversed by adding an excess of calmodulin. In addition, chlorpromazine was able to inhibit the induction of lung nitric oxide synthase, in both species, after LPS administration. Furthermore, chlorpromazine also inhibited arginase activity in mouse lung cytosol.
MeSH terms
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Amino Acid Oxidoreductases / biosynthesis*
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Animals
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Arginase / biosynthesis
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Brain / drug effects*
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Chlorpromazine / pharmacology*
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Citrulline / biosynthesis
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Cytosol / metabolism
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Enzyme Induction / drug effects
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Gene Expression Regulation, Enzymologic / drug effects*
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Lipopolysaccharides / pharmacology
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Lung / metabolism
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Male
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Mice
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Mice, Inbred BALB C
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase
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Rats
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Rats, Sprague-Dawley
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Shock, Septic / etiology
Substances
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Lipopolysaccharides
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Citrulline
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Nitric Oxide
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases
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Arginase
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Chlorpromazine