Abstract
Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under two different conditions: (1) local administration of a monoamine oxidase inhibitor (pargyline, 1, 10 mM), (2) local administration of a Na, K-ATPase inhibitor (ouabain, 10, 100 microM). Further, pretreatment with a vesicle uptake inhibitor (reserpine, 10 microM) augmented these responses. Either condition independently caused endogenous NE release and a brisk increase in dialysate NE levels might occur as a consequence of non-exocytotic release of NE.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antihypertensive Agents / pharmacology
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Axons / chemistry
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Axons / metabolism*
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Cardiotonic Agents / pharmacology
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Cats
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Exocytosis / physiology
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Female
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Ganglia, Sympathetic / drug effects
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Ganglia, Sympathetic / enzymology*
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Heart / innervation
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Male
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Microdialysis
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Monoamine Oxidase Inhibitors / pharmacology
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Norepinephrine / metabolism*
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Ouabain / pharmacology
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Pargyline / pharmacology
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Reserpine / pharmacology
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Sodium / metabolism*
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Sodium-Potassium-Exchanging ATPase / metabolism
Substances
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Antihypertensive Agents
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Cardiotonic Agents
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Monoamine Oxidase Inhibitors
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Ouabain
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Reserpine
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Pargyline
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Sodium
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Sodium-Potassium-Exchanging ATPase
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Norepinephrine