Abstract
PPAR alpha and PPAR gamma represent related but distinct members of the nuclear receptor superfamily. PPAR alpha signaling is modulated by long-chain fatty acids, whereas PPAR gamma ligands are potent antidiabetic agents.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Fatty Acids / chemistry
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Fatty Acids / pharmacology
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Gene Expression Regulation, Enzymologic
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Ligands
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Mice
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Microbodies / drug effects*
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Receptors, Cytoplasmic and Nuclear / physiology*
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Rosiglitazone
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Signal Transduction
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Structure-Activity Relationship
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Thiazoles / pharmacology
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Thiazolidinediones*
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Transcription Factors / physiology*
Substances
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Fatty Acids
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Thiazoles
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Thiazolidinediones
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Transcription Factors
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Rosiglitazone