Abstract
We measured the ability of the cannabinoid agonists delta 9-tetrahydrocannabinol and R(+)-[2,3,-dihydro-5-methyl-3- [(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-napht halenyl) methanone mesylate (WIN 55,212-2) to stimulate guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTP gamma S) binding in mouse brain membranes. delta 9-Tetrahydrocannabinol stimulated [35S]GTP gamma S binding by about 25% as compared to WIN 55,212-2. This is the first report demonstrating that delta 9-tetrahydrocannabinol acts as a partial agonist in stimulating [35S]GTP gamma S binding in the mouse brain.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Benzoxazines
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Brain / drug effects*
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Brain / metabolism
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Dronabinol / pharmacology*
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Guanosine 5'-O-(3-Thiotriphosphate) / metabolism*
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In Vitro Techniques
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Male
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Membranes / metabolism
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Mice
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Morpholines / pharmacology
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Naphthalenes / pharmacology
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Receptors, Cannabinoid
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Receptors, Drug / agonists*
Substances
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Benzoxazines
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Morpholines
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Naphthalenes
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Receptors, Cannabinoid
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Receptors, Drug
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Guanosine 5'-O-(3-Thiotriphosphate)
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(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
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Dronabinol