Abstract
Cyclopentenone prostanoids inhibit virus replication by turning on an intracellular defence response that involves the induction of cytoprotective heat-shock proteins, the modification of viral glycoprotein maturation and the control of NF-kappa B activation. These molecules represent an interesting model for the development of novel antiviral drugs that can affect different targets during the virus life cycle.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Cell Line
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Cyclopentanes / pharmacology*
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Humans
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NF-kappa B / drug effects
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NF-kappa B / metabolism
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Prostaglandins / pharmacology*
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Viral Proteins / antagonists & inhibitors
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Cyclopentanes
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NF-kappa B
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Prostaglandins
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Viral Proteins
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cyclopentenone