Bis-quinolinium cyclophanes: 6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca(2+)-activated K+ channel

J Med Chem. 1998 Jan 1;41(1):2-5. doi: 10.1021/jm970571a.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry*
  • Alkanes / pharmacology
  • Animals
  • Apamin / pharmacology*
  • Brain / physiology
  • Humans
  • Molecular Structure
  • Oocytes / drug effects
  • Oocytes / physiology
  • Potassium Channel Blockers*
  • Potassium Channels*
  • Potassium Channels, Calcium-Activated*
  • Quinolinium Compounds / chemistry*
  • Quinolinium Compounds / pharmacology
  • Rats
  • Small-Conductance Calcium-Activated Potassium Channels
  • Structure-Activity Relationship
  • Xenopus laevis

Substances

  • 6,10-diaza-3(1,3),8(1,4)dibenzena-1,5(1,4)diquinolinacyclodecaphane
  • Alkanes
  • Potassium Channel Blockers
  • Potassium Channels
  • Potassium Channels, Calcium-Activated
  • Quinolinium Compounds
  • Small-Conductance Calcium-Activated Potassium Channels
  • Apamin