Abstract
Increasing [Ca2+]e from 1.3 4 mM had little effect on basal phospholipase C activity in baby hamster kidney (BHK) cells stably expressing either type 1alpha metabotropic glutamate (mGlu1alpha) or M3-muscarinic (m3) receptors, but enhanced agonist-stimulated phosphoinositide hydrolysis in BHK-mGlu1alpha, but not BHK-m3 cells, demonstrating that Ca2+(e) selectively modulates phosphoinositide signalling stimulated by this receptor subtype.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arecoline / pharmacology
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Calcium / pharmacology*
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Cell Line
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Cricetinae
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Cycloleucine / analogs & derivatives*
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Cycloleucine / pharmacology
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Enzyme Activation
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Excitatory Amino Acid Agonists / pharmacology*
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Inositol Phosphates / biosynthesis*
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Kidney / drug effects
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Kidney / physiology
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Methacholine Chloride / pharmacology
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Muscarinic Agonists / pharmacology
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Quisqualic Acid / pharmacology*
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Receptors, Metabotropic Glutamate / drug effects
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Receptors, Metabotropic Glutamate / physiology*
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Receptors, Muscarinic / drug effects
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Type C Phospholipases / metabolism
Substances
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Excitatory Amino Acid Agonists
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Inositol Phosphates
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Muscarinic Agonists
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Receptors, Metabotropic Glutamate
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Receptors, Muscarinic
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metabotropic glutamate receptor type 1
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Cycloleucine
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Methacholine Chloride
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1-amino-1,3-dicarboxycyclopentane
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Arecoline
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Quisqualic Acid
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Type C Phospholipases
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Calcium