Functional effects of FGF-13 on human lung fibroblasts, dermal microvascular endothelial cells, and aortic smooth muscle cells

Biochem Biophys Res Commun. 1998 Sep 8;250(1):137-42. doi: 10.1006/bbrc.1998.9279.

Abstract

We studied the effects of FGF-13 and FGF-2 on human lung fibroblasts, dermal microvascular endothelial cells, and aortic smooth muscle cells. FGF-13 induced cell growth of lung fibroblasts and aortic smooth muscle cells but had no effect on dermal vascular endothelial cells. FGF-2 induced cell growth in all the three cell types. FGF-13 and FGF-2 had little effect on IL-6 production by lung fibroblasts and aortic smooth muscle cells and substantially enhanced that induced by IL-1alpha. In contrast, FGF-13 and FGF-2 had little effect on IL-6 production by dermal vascular endothelial cells, either alone or in synergy with IL-1alpha.

MeSH terms

  • Aorta / cytology
  • Aorta / drug effects*
  • Aorta / metabolism
  • Cell Division / drug effects
  • Cells, Cultured
  • Dinoprostone / metabolism
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Fibroblast Growth Factor 2 / pharmacology
  • Fibroblast Growth Factors / pharmacology*
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism
  • Humans
  • Interleukin-1 / pharmacology
  • Interleukin-6 / metabolism
  • Lung / cytology
  • Lung / drug effects*
  • Lung / metabolism
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects*
  • Muscle, Smooth, Vascular / metabolism

Substances

  • Interleukin-1
  • Interleukin-6
  • Fibroblast Growth Factor 2
  • fibroblast growth factor 13
  • Fibroblast Growth Factors
  • Dinoprostone