Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

Br J Pharmacol. 1998 Nov;125(5):924-47. doi: 10.1038/sj.bjp.0702164.
No abstract available

Publication types

  • Review

MeSH terms

  • Allosteric Regulation
  • Animals
  • DNA Mutational Analysis
  • Dose-Response Relationship, Drug
  • GTP-Binding Proteins / metabolism
  • Humans
  • Ion Channel Gating*
  • Ion Channels / agonists
  • Ion Channels / genetics
  • Protein Conformation
  • Receptors, Cell Surface / agonists*
  • Receptors, Cell Surface / genetics*
  • Receptors, N-Methyl-D-Aspartate / genetics
  • Structure-Activity Relationship

Substances

  • Ion Channels
  • Receptors, Cell Surface
  • Receptors, N-Methyl-D-Aspartate
  • GTP-Binding Proteins