Abstract
The role of L-,N-, P- and Q-type voltage-dependent calcium channels in K+-induced release of [3H]adenine nucleotides from rat brain cortical synaptosomes was investigated. Cd2+, a non-specific blocker of calcium channels, inhibited by 69% the release of the nucleotides induced by 33 mM K+. Nifedipine, omega-Conotoxin GVIA and omega-Agatoxin IVA had no effect whereas omega-Conotoxin MVIIC inhibited by 62% the K+ induced release of adenine nucleotides in rat brain cortical synaptosomes. It is concluded that Q-type calcium channels are directly involved in the release of adenine nucleotides in rat brain cortical synaptosomes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine Nucleotides / metabolism*
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Animals
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Cadmium / pharmacology
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Calcium Channel Blockers / pharmacology*
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Calcium Channels / drug effects
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Calcium Channels / physiology*
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Cerebral Cortex / metabolism*
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Female
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Male
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Mollusk Venoms / pharmacology
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Nifedipine / pharmacology
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Peptides / pharmacology
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Potassium / pharmacology*
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Rats
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Rats, Wistar
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Spider Venoms / pharmacology
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Synaptosomes / metabolism*
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Tritium
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omega-Agatoxin IVA
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omega-Conotoxin GVIA
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omega-Conotoxins*
Substances
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Adenine Nucleotides
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Calcium Channel Blockers
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Calcium Channels
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Mollusk Venoms
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Peptides
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Spider Venoms
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omega-Agatoxin IVA
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omega-Conotoxins
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Cadmium
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Tritium
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Conus magus toxin
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omega-Conotoxin GVIA
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Nifedipine
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Potassium