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Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect.
Bavo F, de-Jong H, Petersen J, Falk-Petersen CB, Löffler R, Sparrow E, Rostrup F, Eliasen JN, Wilhelmsen KS, Barslund K, Bundgaard C, Nielsen B, Kristiansen U, Wellendorph P, Bogdanov Y, Frølund B. Bavo F, et al. Among authors: falk petersen cb. J Med Chem. 2021 Dec 23;64(24):17795-17812. doi: 10.1021/acs.jmedchem.1c00290. Epub 2021 Dec 15. J Med Chem. 2021. PMID: 34908407
Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1.
Kickinger S, Lie MEK, Suemasa A, Al-Khawaja A, Fujiwara K, Watanabe M, Wilhelmsen KS, Falk-Petersen CB, Frølund B, Shuto S, Ecker GF, Wellendorph P. Kickinger S, et al. Among authors: falk petersen cb. Front Chem. 2021 Sep 14;9:736457. doi: 10.3389/fchem.2021.736457. eCollection 2021. Front Chem. 2021. PMID: 34595152 Free PMC article.
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
Krall J, Bavo F, Falk-Petersen CB, Jensen CH, Nielsen JO, Tian Y, Anglani V, Kongstad KT, Piilgaard L, Nielsen B, Gloriam DE, Kehler J, Jensen AA, Harpsøe K, Wellendorph P, Frølund B. Krall J, et al. Among authors: falk petersen cb. J Med Chem. 2019 Mar 14;62(5):2798-2813. doi: 10.1021/acs.jmedchem.9b00131. Epub 2019 Feb 27. J Med Chem. 2019. PMID: 30763084
Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs.
Krall J, Jensen CH, Bavo F, Falk-Petersen CB, Haugaard AS, Vogensen SB, Tian Y, Nittegaard-Nielsen M, Sigurdardóttir SB, Kehler J, Kongstad KT, Gloriam DE, Clausen RP, Harpsøe K, Wellendorph P, Frølund B. Krall J, et al. Among authors: falk petersen cb. J Med Chem. 2017 Nov 9;60(21):9022-9039. doi: 10.1021/acs.jmedchem.7b01351. Epub 2017 Oct 30. J Med Chem. 2017. PMID: 29028338
11 results