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Page 1
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Pluymers W, Pais G, Van Maele B, Pannecouque C, Fikkert V, Burke TR Jr, De Clercq E, Witvrouw M, Neamati N, Debyser Z. Pluymers W, et al. Among authors: fikkert v. Antimicrob Agents Chemother. 2002 Oct;46(10):3292-7. doi: 10.1128/AAC.46.10.3292-3297.2002. Antimicrob Agents Chemother. 2002. PMID: 12234864 Free PMC article.
Discovery of a small-molecule HIV-1 integrase inhibitor-binding site.
Al-Mawsawi LQ, Fikkert V, Dayam R, Witvrouw M, Burke TR Jr, Borchers CH, Neamati N. Al-Mawsawi LQ, et al. Among authors: fikkert v. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10080-5. doi: 10.1073/pnas.0511254103. Epub 2006 Jun 19. Proc Natl Acad Sci U S A. 2006. PMID: 16785440 Free PMC article.
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Hantson A, Fikkert V, Van Remoortel B, Pannecouque C, Cherepanov P, Matthews B, Holan G, De Clercq E, Vandamme AM, Debyser Z, Witvrouw M. Hantson A, et al. Among authors: fikkert v. Antivir Chem Chemother. 2005;16(4):253-66. doi: 10.1177/095632020501600405. Antivir Chem Chemother. 2005. PMID: 16130523 Free article.
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
Witvrouw M, Fikkert V, Pluymers W, Matthews B, Mardel K, Schols D, Raff J, Debyser Z, De Clercq E, Holan G, Pannecouque C. Witvrouw M, et al. Among authors: fikkert v. Mol Pharmacol. 2000 Nov;58(5):1100-8. Mol Pharmacol. 2000. PMID: 11040059