Forsch RA[au] - Search Results

Year	Number of Results
1984	4
1985	3
1986	2
1987	2
1988	2
1989	2
1991	3
1992	2
1995	2
1998	1
1999	2
2000	2
2002	2
2003	1
2004	3
2005	1
2024	0

1

Synthesis and in vitro antitumor activity of thiophene analogues of 5-chloro-5,8-dideazafolic acid and 2-methyl-2-desamino-5-chloro-5,8-dideazafolic acid.

Forsch RA, Wright JE, Rosowsky A. Forsch RA, et al. Bioorg Med Chem. 2002 Jun;10(6):2067-76. doi: 10.1016/s0968-0896(02)00018-4. Bioorg Med Chem. 2002. PMID: 11937365

2

Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.

Rosowsky A, Forsch RA, Wright JE. Rosowsky A, et al. Among authors: forsch ra. J Med Chem. 2004 Dec 30;47(27):6958-63. doi: 10.1021/jm040122s. J Med Chem. 2004. PMID: 15615544

3

Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.

Rosowsky A, Papoulis AT, Forsch RA, Queener SF. Rosowsky A, et al. Among authors: forsch ra. J Med Chem. 1999 Mar 25;42(6):1007-17. doi: 10.1021/jm980572i. J Med Chem. 1999. PMID: 10090784

4

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.

Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, Hynes JB, Boyle FT, Peters GJ, Pinedo HM, et al. Westerhof GR, et al. Among authors: forsch ra. Mol Pharmacol. 1995 Sep;48(3):459-71. Mol Pharmacol. 1995. PMID: 7565626

5

Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.

Rosowsky A, Forsch RA, Freisheim JH, Danenberg PV, Moran RG, Wick MM. Rosowsky A, et al. Among authors: forsch ra. J Med Chem. 1986 Oct;29(10):1872-6. doi: 10.1021/jm00160a014. J Med Chem. 1986. PMID: 2428979

6

Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.

Rosowsky A, Forsch RA, Queener SF. Rosowsky A, et al. Among authors: forsch ra. J Med Chem. 2002 Jan 3;45(1):233-41. doi: 10.1021/jm010407u. J Med Chem. 2002. PMID: 11754594

7

Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.

Rosowsky A, Bader H, Forsch RA, Moran RG, Freisheim JH. Rosowsky A, et al. Among authors: forsch ra. J Med Chem. 1988 Apr;31(4):763-8. doi: 10.1021/jm00399a013. J Med Chem. 1988. PMID: 3351853

8

Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.

Rosowsky A, Moran RC, Forsch RA, Radike-Smith M, Colman PD, Wick MM, Freisheim JH. Rosowsky A, et al. Among authors: forsch ra. Biochem Pharmacol. 1986 Oct 1;35(19):3327-33. doi: 10.1016/0006-2952(86)90431-4. Biochem Pharmacol. 1986. PMID: 3768024

9

Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.

Rosowsky A, Wright JE, Vaidya CM, Forsch RA, Bader H. Rosowsky A, et al. Among authors: forsch ra. J Med Chem. 2000 Apr 20;43(8):1620-34. doi: 10.1021/jm990630f. J Med Chem. 2000. PMID: 10780919

10

The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine.

Rosowsky A, Wright JE, Vaidya CM, Forsch RA. Rosowsky A, et al. Among authors: forsch ra. Pharmacol Ther. 2000 Mar;85(3):191-205. doi: 10.1016/s0163-7258(99)00055-8. Pharmacol Ther. 2000. PMID: 10739874

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