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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1998 1
2000 1
2003 2
2004 1
2010 2
2011 6
2012 1
2013 1
2014 1
2015 1
2017 2
2018 3
2019 2
2020 3
2021 3
2022 2
2024 0

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33 results

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Page 1
Development of novel drugs for human African trypanosomiasis.
Brun R, Don R, Jacobs RT, Wang MZ, Barrett MP. Brun R, et al. Among authors: jacobs rt. Future Microbiol. 2011 Jun;6(6):677-91. doi: 10.2217/fmb.11.44. Future Microbiol. 2011. PMID: 21707314 Free article. Review.
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.
Priebbenow DL, Mathiew M, Shi DH, Harjani JR, Beveridge JG, Chavchich M, Edstein MD, Duffy S, Avery VM, Jacobs RT, Brand S, Shackleford DM, Wang W, Zhong L, Lee G, Tay E, Barker H, Crighton E, White KL, Charman SA, De Paoli A, Creek DJ, Baell JB. Priebbenow DL, et al. Among authors: jacobs rt. J Med Chem. 2021 Apr 8;64(7):4150-4162. doi: 10.1021/acs.jmedchem.1c00044. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33759519
Boron-based drugs as antiprotozoals.
Jacobs RT, Plattner JJ, Keenan M. Jacobs RT, et al. Curr Opin Infect Dis. 2011 Dec;24(6):586-92. doi: 10.1097/QCO.0b013e32834c630e. Curr Opin Infect Dis. 2011. PMID: 22001943 Review.
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.
Zhang N, Zoltner M, Leung KF, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang YK, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC. Zhang N, et al. Among authors: jacobs rt. PLoS Pathog. 2018 Feb 9;14(2):e1006850. doi: 10.1371/journal.ppat.1006850. eCollection 2018 Feb. PLoS Pathog. 2018. PMID: 29425238 Free PMC article.
Optimized Pyridazinone Nutrient Channel Inhibitors Are Potent and Specific Antimalarial Leads.
Butler MM, Waidyarachchi SL, Shao J, Nguyen ST, Ding X, Cardinale SC, Morin LR, Kwasny SM, Ito M, Gezelle J, Jiménez-Díaz MB, Angulo-Barturen I, Jacobs RT, Burrows JN, Aron ZD, Bowlin TL, Desai SA. Butler MM, et al. Among authors: jacobs rt. Mol Pharmacol. 2022 Sep;102(3):172-182. doi: 10.1124/molpharm.122.000549. Epub 2022 Jul 7. Mol Pharmacol. 2022. PMID: 35798366 Free PMC article.
State of the art in African trypanosome drug discovery.
Jacobs RT, Nare B, Phillips MA. Jacobs RT, et al. Curr Top Med Chem. 2011;11(10):1255-74. doi: 10.2174/156802611795429167. Curr Top Med Chem. 2011. PMID: 21401507 Free PMC article. Review.
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.
Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD. Lunde CS, et al. Among authors: jacobs rt. Nat Commun. 2019 Jun 27;10(1):2816. doi: 10.1038/s41467-019-10687-y. Nat Commun. 2019. PMID: 31249291 Free PMC article.
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
Mowbray CE, Braillard S, Glossop PA, Whitlock GA, Jacobs RT, Speake J, Pandi B, Nare B, Maes L, Yardley V, Freund Y, Wall RJ, Carvalho S, Bello D, Van den Kerkhof M, Caljon G, Gilbert IH, Corpas-Lopez V, Lukac I, Patterson S, Zuccotto F, Wyllie S. Mowbray CE, et al. Among authors: jacobs rt. J Med Chem. 2021 Nov 11;64(21):16159-16176. doi: 10.1021/acs.jmedchem.1c01437. Epub 2021 Oct 28. J Med Chem. 2021. PMID: 34711050 Free PMC article.
A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones.
Pou S, Dodean RA, Frueh L, Liebman KM, Gallagher RT, Jin H, Jacobs RT, Nilsen A, Stuart DR, Doggett JS, Riscoe MK, Winter RW. Pou S, et al. Among authors: jacobs rt. Org Process Res Dev. 2021 Aug 20;25(8):1841-1852. doi: 10.1021/acs.oprd.1c00099. Epub 2021 Aug 4. Org Process Res Dev. 2021. PMID: 35110959 Free PMC article.
Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.
Padilla AM, Wang W, Akama T, Carter DS, Easom E, Freund Y, Halladay JS, Liu Y, Hamer SA, Hodo CL, Wilkerson GK, Orr D, White B, George A, Shen H, Jin Y, Wang MZ, Tse S, Jacobs RT, Tarleton RL. Padilla AM, et al. Among authors: jacobs rt. Nat Microbiol. 2022 Oct;7(10):1536-1546. doi: 10.1038/s41564-022-01211-y. Epub 2022 Sep 5. Nat Microbiol. 2022. PMID: 36065062 Free PMC article.
33 results