Keough DT[au] - Search Results

Year	Number of Results
1974	1
1978	1
1980	1
1982	2
1983	1
1984	1
1985	1
1987	2
1988	1
1989	2
1990	1
1991	2
1998	2
1999	1
2002	1
2005	2
2006	1
2009	2
2010	1
2011	3
2012	3
2013	4
2014	1
2015	5
2016	1
2017	5
2018	2
2019	2
2021	2
2022	1
2023	1
2024	0

1

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs.

de Jersey J, Holý A, Hocková D, Naesens L, Keough DT, Guddat LW. de Jersey J, et al. Among authors: keough dt. Curr Top Med Chem. 2011;11(16):2085-102. doi: 10.2174/156802611796575911. Curr Top Med Chem. 2011. PMID: 21619515 Free article. Review.

2

N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.

Vaňková K, Keough DT, Hocková D, Guddat LW, Janeba Z. Vaňková K, et al. Among authors: keough dt. ChemMedChem. 2023 Aug 1;18(15):e202300211. doi: 10.1002/cmdc.202300211. Epub 2023 Jun 20. ChemMedChem. 2023. PMID: 37264975

3

Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.

Klejch T, Keough DT, King G, Doleželová E, Česnek M, Buděšínský M, Zíková A, Janeba Z, Guddat LW, Hocková D. Klejch T, et al. Among authors: keough dt. J Med Chem. 2022 Mar 10;65(5):4030-4057. doi: 10.1021/acs.jmedchem.1c01881. Epub 2022 Feb 17. J Med Chem. 2022. PMID: 35175749

4

Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis.

Eng WS, Keough DT, Hockova D, Winzor DJ, Guddat LW. Eng WS, et al. Among authors: keough dt. Biochimie. 2017 Apr;135:6-14. doi: 10.1016/j.biochi.2016.12.020. Epub 2017 Jan 9. Biochimie. 2017. PMID: 28082125

5

Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.

Keough DT, Wun SJ, Baszczyňski O, Eng WS, Špaček P, Panjikar S, Naesens L, Pohl R, Rejman D, Hocková D, Ferrero RL, Guddat LW. Keough DT, et al. J Med Chem. 2021 May 13;64(9):5710-5729. doi: 10.1021/acs.jmedchem.0c02184. Epub 2021 Apr 23. J Med Chem. 2021. PMID: 33891818

6

Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.

Eng WS, Rejman D, Pohl R, West NP, Woods K, Naesens LMJ, Keough DT, Guddat LW. Eng WS, et al. Among authors: keough dt. Eur J Med Chem. 2018 Nov 5;159:10-22. doi: 10.1016/j.ejmech.2018.09.039. Epub 2018 Sep 19. Eur J Med Chem. 2018. PMID: 30265958

7

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.

Keough DT, Rejman D, Pohl R, Zborníková E, Hocková D, Croll T, Edstein MD, Birrell GW, Chavchich M, Naesens LMJ, Pierens GK, Brereton IM, Guddat LW. Keough DT, et al. ACS Chem Biol. 2018 Jan 19;13(1):82-90. doi: 10.1021/acschembio.7b00916. Epub 2017 Dec 5. ACS Chem Biol. 2018. PMID: 29161011

8

Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.

Frydrych J, Keough DT, Chavchich M, Travis J, Dračínský M, Edstein MD, Guddat LW, Hocková D, Janeba Z. Frydrych J, et al. Among authors: keough dt. Eur J Med Chem. 2021 Jul 5;219:113416. doi: 10.1016/j.ejmech.2021.113416. Epub 2021 Apr 3. Eur J Med Chem. 2021. PMID: 33887682

9

Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP.

Terán D, Doleželová E, Keough DT, Hocková D, Zíková A, Guddat LW. Terán D, et al. Among authors: keough dt. FEBS J. 2019 Dec;286(23):4721-4736. doi: 10.1111/febs.14987. Epub 2019 Jul 24. FEBS J. 2019. PMID: 31287615 Free article.

10

Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

Kaiser MM, Baszczyňski O, Hocková D, Poštová-Slavětínská L, Dračínský M, Keough DT, Guddat LW, Janeba Z. Kaiser MM, et al. Among authors: keough dt. ChemMedChem. 2017 Jul 20;12(14):1133-1141. doi: 10.1002/cmdc.201700293. Epub 2017 Jul 11. ChemMedChem. 2017. PMID: 28628279

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