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Page 1
Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors.
ACS Chem Neurosci. 2021 Dec 15;12(24):4524-4534. doi: 10.1021/acschemneuro.1c00557. Epub 2021 Dec 2.
ACS Chem Neurosci. 2021.
PMID: 34855359
Free PMC article.
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.
Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW.
Temple KJ, et al. Among authors: maeng jg.
Bioorg Med Chem Lett. 2016 Nov 15;26(22):5481-5486. doi: 10.1016/j.bmcl.2016.10.020. Epub 2016 Oct 11.
Bioorg Med Chem Lett. 2016.
PMID: 27777004
Free PMC article.
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Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study.
Werfel TA, Hicks DJ, Rahman B, Bendeman WE, Duvernay MT, Maeng JG, Hamm H, Lavieri RR, Joly MM, Pulley JM, Elion DL, Brantley-Sieders DM, Cook RS.
Werfel TA, et al. Among authors: maeng jg.
Mol Cancer Ther. 2020 Dec;19(12):2454-2464. doi: 10.1158/1535-7163.MCT-19-1106. Epub 2020 Oct 8.
Mol Cancer Ther. 2020.
PMID: 33033174
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Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.
Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE.
Duvernay MT, et al. Among authors: maeng jg.
Mol Pharmacol. 2017 Jan;91(1):39-47. doi: 10.1124/mol.116.106666. Epub 2016 Oct 26.
Mol Pharmacol. 2017.
PMID: 27784794
Free PMC article.
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Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin.
Temple KJ, Duvernay MT, Young SE, Wen W, Wu W, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW.
Temple KJ, et al. Among authors: maeng jg.
J Med Chem. 2016 Aug 25;59(16):7690-5. doi: 10.1021/acs.jmedchem.6b00928. Epub 2016 Aug 8.
J Med Chem. 2016.
PMID: 27482618
Free PMC article.
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