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Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors.
Bertron JL, Duvernay MT, Mitchell SG, Smith ST, Maeng JG, Blobaum AL, Davis DC, Meiler J, Hamm HE, Lindsley CW. Bertron JL, et al. Among authors: maeng jg. ACS Chem Neurosci. 2021 Dec 15;12(24):4524-4534. doi: 10.1021/acschemneuro.1c00557. Epub 2021 Dec 2. ACS Chem Neurosci. 2021. PMID: 34855359 Free PMC article.
Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin.
Temple KJ, Duvernay MT, Young SE, Wen W, Wu W, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW. Temple KJ, et al. Among authors: maeng jg. J Med Chem. 2016 Aug 25;59(16):7690-5. doi: 10.1021/acs.jmedchem.6b00928. Epub 2016 Aug 8. J Med Chem. 2016. PMID: 27482618 Free PMC article.