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Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5.
Selkirk JV, Dines KC, Yan YG, Ching N, Dalvie D, Biswas S, Bortolato A, Schkeryantz JM, Lopez C, Ruiz I, Hargreaves R. Selkirk JV, et al. J Pharmacol Exp Ther. 2021 Dec;379(3):386-399. doi: 10.1124/jpet.121.000741. Epub 2021 Sep 17. J Pharmacol Exp Ther. 2021. PMID: 34535564
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator.
Surapaneni S, Yerramilli U, Bai A, Dalvie D, Brooks J, Wang X, Selkirk JV, Yan YG, Zhang P, Hargreaves R, Kumar G, Palmisano M, Tran JQ. Surapaneni S, et al. Among authors: selkirk jv. Drug Metab Dispos. 2021 May;49(5):405-419. doi: 10.1124/dmd.120.000220. Epub 2021 Mar 4. Drug Metab Dispos. 2021. PMID: 33674268 Clinical Trial.
Investigation into MAO B-Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of (S)-Enantiomer of Indaneamine (RP101075) by MAO B.
Bai A, Shanmugasundaram V, Selkirk JV, Surapaneni S, Dalvie D. Bai A, et al. Among authors: selkirk jv. Drug Metab Dispos. 2021 Aug;49(8):601-609. doi: 10.1124/dmd.121.000447. Epub 2021 May 19. Drug Metab Dispos. 2021. PMID: 34011531
Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function.
Schwarz DA, Allen MM, Petroski RE, Pomeroy JE, Heise CE, Mistry MS, Selkirk JV, Nottebaum LM, Grey J, Zhang M, Goodfellow VS, Maki RA. Schwarz DA, et al. Among authors: selkirk jv. Mol Cell Endocrinol. 2006 Oct 19;259(1-2):1-9. doi: 10.1016/j.mce.2006.07.003. Epub 2006 Sep 20. Mol Cell Endocrinol. 2006. PMID: 16987592
19 results