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Page 1
Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties.
Bioorg Med Chem Lett. 2007 Jan 15;17(2):553-7. doi: 10.1016/j.bmcl.2006.09.072. Epub 2006 Dec 15.
Bioorg Med Chem Lett. 2007.
PMID: 17174551
3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.
Jaffar M, Phillips RM, Williams KJ, Mrema I, Cole C, Wind NS, Ward TH, Stratford IJ, Patterson AV.
Jaffar M, et al. Among authors: wind ns.
Biochem Pharmacol. 2003 Oct 1;66(7):1199-206. doi: 10.1016/s0006-2952(03)00452-0.
Biochem Pharmacol. 2003.
PMID: 14505799
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Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro.
Chinje EC, Cowen RL, Feng J, Sharma SP, Wind NS, Harris AL, Stratford IJ.
Chinje EC, et al. Among authors: wind ns.
Mol Pharmacol. 2003 Jun;63(6):1248-55. doi: 10.1124/mol.63.6.1248.
Mol Pharmacol. 2003.
PMID: 12761334
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Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure.
Cowen RL, Williams KJ, Chinje EC, Jaffar M, Sheppard FC, Telfer BA, Wind NS, Stratford IJ.
Cowen RL, et al. Among authors: wind ns.
Cancer Res. 2004 Feb 15;64(4):1396-402. doi: 10.1158/0008-5472.can-03-2698.
Cancer Res. 2004.
PMID: 14973055
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Multidrug resistance in breast cancer: from in vitro models to clinical studies.
Wind NS, Holen I.
Wind NS, et al.
Int J Breast Cancer. 2011;2011:967419. doi: 10.4061/2011/967419. Epub 2011 Feb 24.
Int J Breast Cancer. 2011.
PMID: 22332018
Free PMC article.
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Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC).
Arthurs CL, Raftery J, Whitby HL, Whitehead RC, Wind NS, Stratford IJ.
Arthurs CL, et al. Among authors: wind ns.
Bioorg Med Chem Lett. 2007 Nov 1;17(21):5974-7. doi: 10.1016/j.bmcl.2007.07.070. Epub 2007 Aug 21.
Bioorg Med Chem Lett. 2007.
PMID: 17870533
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