By using a combination of genetic, pharmacological, and anatomical approaches, we show
that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy …

… approach has been proven clinically useful in ligand-gated GABA type A receptors, to date
no clinically available compounds have been produced that act at an allosteric site on a G …

… All introns in the PAH gene begin and end with the canonical GT and AG dinucleotide,
respectively. The final 17 nucleotides at the 3' end of each intron contain only one AG …

The globus pallidus (GP) is a key GABAergic nucleus in the basal ganglia (BG). The
predominant input to the GP is an inhibitory striatal projection that forms the first synapse in the …

Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine,
Houston, Texas 77030 Received November 13, 1984 abstract: A full-length human …

Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4 (mGluR4) have
been proposed as a novel therapeutic approach for the treatment of Parkinson's disease. …

Phenylketonuria (PKU) is an autosomal recessive human genetic disorder caused by a
deficiency of hepatic phenylalanine hydroxy-lase (PAH, phenylalanine 4-monooxygenase, EC …

HUMAN herpesviruses are responsible for a variety of diseases. They are divided into three
subfamilies: alpha includes herpes simplex viruses (HSV-1 and HSV-2) and varicella-zoster …

The discovery of a novel series of potent and selective T-type calcium channel antagonists
is reported. Initial optimization of high-throughput screening leads afforded a 1,4-substituted …

A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by
forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyl …