Monoclonal antibodies to choline acetyltransferase and a histochemical method for the
concurrent demonstration of acetylcholinesterase and horseradish peroxidase were used to …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants …

The organization of projections from the cholinergic neurons of the basal forebrain to
neocortex and associated structures was investigated in the rhesus monkey with the help of …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…

The cellular and subcellular distributions of the glutamate transporter subtypes EAACl, CLT-1,
and CIAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize …

The global endemic of cardiovascular diseases calls for improved risk assessment and
treatment. Here, we describe an association between myocardial infarction (MI) and a common …

The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in
synaptosomal high‐affinity glutamate transport have been observed. In experimental models…