[HTML][HTML] Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

…, NI Gueorguieva, H Tharagonnet, AJ Townsend… - Cell, 2013 - cell.com
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic
context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides …

New Zealand Threat Classification System manual.

AJ Townsend, PJ Lange, CAJ Duffy, CM Miskelly… - 2008 - cabidigitallibrary.org
The New Zealand Threat Classification System provides a tool for assigning a threat status
to candidate taxa. In this revision of the 2002 system, substantial changes include the …

Deep machine learning provides state-of-the-art performance in image-based plant phenotyping

MP Pound, JA Atkinson, AJ Townsend, MH Wilson… - …, 2017 - academic.oup.com
In plant phenotyping, it has become important to be able to measure many features on large
image sets in order to aid genetic discovery. The size of the datasets, now often captured …

Threatened and uncommon plants of New Zealand (2008 revision)

…, R Hitchmough, AJ Townsend - New Zealand Journal …, 2009 - Taylor & Francis
A reappraisal of the conservation status of the indigenous New Zealand vascular plant flora
is presented using the 2008 version of the threat classification system developed for the New …

An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue.

P Terrier, AJ Townsend, JM Coindre… - The American journal …, 1990 - ncbi.nlm.nih.gov
Glutathione S-transferases (GSTs), a family of isoenzymes that play an important role in
protecting cells from cytotoxic and carcinogenic agents, can be separated by biochemical and …

[HTML][HTML] Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification: mechanism of GST …

…, SK Diah, E Schneider, AJ Townsend - Journal of Biological …, 1998 - ASBMB
To examine the role of multidrug resistance protein 1 (MRP1) and glutathione S-transferases
(GSTs) in cellular resistance to antineoplastic drugs, derivatives of MCF7 breast carcinoma …

Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin

C Peklak-Scott, PK Smitherman, AJ Townsend… - Molecular cancer …, 2008 - AACR
Cells expressing elevated levels of allelic variants of human glutathione S-transferase P1 (GSTP1)
and/or efflux transporters, MRP1 or MRP2, were used to evaluate the role of GSTP1-1 …

Aldh3a1 protects human corneal epithelial cells from ultraviolet-and 4-hydroxy-2-nonenal-induced oxidative damage

A Pappa, C Chen, Y Koutalos, AJ Townsend… - Free Radical Biology …, 2003 - Elsevier
Aldehyde dehydrogenase 3A1 (ALDH3A1) is one of the most abundant proteins found in
corneal epithelial cells of mammalian species, with several postulated protective roles that …

Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux

…, TE Kute, PK Smitherman, AJ Townsend - Molecular …, 2006 - ASPET
Based upon several previous reports, no consistent relationship between multidrug resistance
protein 1 (MRP1, ABCC1) expression and cellular sensitivity to mitoxantrone (MX) toxicity …

Lung tumor promotion by curcumin

…, RB D'Agostino Jr, TP McCoy, AJ Townsend… - …, 2009 - academic.oup.com
Curcumin exhibits anti-inflammatory and antitumor activity and is being tested in clinical trials
as a chemopreventive agent for colon cancer. Curcumin's chemopreventive activity was …