Chlorambucil drug resistance in chronic lymphocytic leukemia: the emerging role of DNA repair
…, G Christodoulopoulos, A Belenkov, A Malapetsa… - Clinical Cancer …, 2001 - AACR
Various mechanisms have been implicated in nitrogen mustard drug resistance. The role of
these mechanisms in the development of chlorambucil drug resistance in chronic …
these mechanisms in the development of chlorambucil drug resistance in chronic …
Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences
…, K Hübner, A Bauer, I Orlova, A Malapetsa… - Mammalian …, 2001 - Springer
The Oct-4 gene encodes a transcription factor that is specifically expressed in embryonic stem
cells and germ cells of the mouse embryo. Cells that differentiate into somatic tissues lose …
cells and germ cells of the mouse embryo. Cells that differentiate into somatic tissues lose …
Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD
…, V Bello, J Bergeron, FY Han, Y Yan, A Malapetsa… - Cancer research, 2002 - AACR
We have recently completed screening of the National Cancer Institute human tumor cell
line panel and demonstrated that among four nucleotide excision repair proteins (XPA, XPB, …
line panel and demonstrated that among four nucleotide excision repair proteins (XPA, XPB, …
Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards
R Geleziunas, A McQuillan, A Malapetsa… - JNCI: Journal of the …, 1991 - academic.oup.com
Resistance to the nitrogen mustards in patients with chronic lymphocytic leukemia (CLL)
correlates with an enhanced removal of melphalan-induced DNA interstrand cross-links. This …
correlates with an enhanced removal of melphalan-induced DNA interstrand cross-links. This …
Chlorambucil induction of HsRad51 in B-cell chronic lymphocytic leukemia
G Christodoulopoulos, A Malapetsa, H Schipper… - Clinical cancer …, 1999 - AACR
Our previous studies with B-cell chronic lymphocytic leukemia (B-CLL) have suggested that
one of the mechanisms of nitrogen mustard (NM) drug resistance is increased repair of drug-…
one of the mechanisms of nitrogen mustard (NM) drug resistance is increased repair of drug-…
DNA repair protein levels vis-a-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program
Z Xu, ZP Chen, A Malapetsa, M Alaoui-Jamali… - Anti-cancer …, 2002 - journals.lww.com
Nucleotide excision repair (NER) is a multi-enzyme DNA repair pathway in eukaryotes.
Several NER genes in this pathway including XPB, XPD, XPA and ERCC-1 have been …
Several NER genes in this pathway including XPB, XPD, XPA and ERCC-1 have been …
Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients
…, Y Garcia, D Tampieri, G Mohr, A Malapetsa… - Canadian journal of …, 1999 - cambridge.org
Background:Adjuvant nitrosourea chemotherapy fails to prolong survival significantly as many
tumors demonstrate resistance to these drugs. It has been documented in cell lines that O6…
tumors demonstrate resistance to these drugs. It has been documented in cell lines that O6…
Evidence for Nucleotide Excision Repair as a Modifying Factor ofO 6-Methylguanine-DNA Methyltransferase-Mediated Innate Chloroethylnitrosourea Resistance in …
ZP Chen, A Malapetsa, A McQuillan… - Molecular …, 1997 - ASPET
We examined the O 6 -methylguanine-DNA methyltransferase (MGMT) protein as well as
MGMT activity levels and the excision repair cross-complementing rodent repair deficiency …
MGMT activity levels and the excision repair cross-complementing rodent repair deficiency …
Poly (ADP-ribose) polymerase can bind melphalan damaged DNA
J Bramson, J Prevost, A Malapetsa, AJ Noe, GG Poirier… - Cancer research, 1993 - AACR
As a means of identifying damage recognition proteins involved in repair of nitrogen mustard
lesions in chronic lymphocytic leukemia, we performed Southwestern analysis using a …
lesions in chronic lymphocytic leukemia, we performed Southwestern analysis using a …
Nucleotide excision repair protein levels vis-à-vis anticancer drug resistance in 60 human tumor cell lines.
ZP Chen, A Malapetsa, A Monks, TG Myers… - Ai zheng= Aizheng …, 2002 - europepmc.org
BACKGROUND & OBJECTIVE: Nucleotide excision repair (NER) is a multi-enzyme DNA
repair system in eukaryotes. Several NER genes in this system including XPA, XPB, ERCC1, …
repair system in eukaryotes. Several NER genes in this system including XPA, XPB, ERCC1, …