Recent anticancer cytotoxic agents
P Cozzi, N Mongelli, A Suarato - Current Medicinal Chemistry …, 2004 - ingentaconnect.com
In spite of the impressive progress in diagnosis, surgery and therapy that occurred since the
Sixties, the overall cancer mortality is still high and the medical need is largely unmet. A …
Sixties, the overall cancer mortality is still high and the medical need is largely unmet. A …
Preclinical evaluation of polymer-bound doxorubicin
…, M Grandi, M Ripamonti, M Farao, A Suarato - Journal of controlled …, 1992 - Elsevier
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers (Mw approximately 20 000) were
synthesised to contain doxorubicin (DOX) ( approximately 7 wt% ) attached to the polymer …
synthesised to contain doxorubicin (DOX) ( approximately 7 wt% ) attached to the polymer …
Effectiveness of anthracycline against experimental prion disease in Syrian hamsters
Prion diseases are transmissible neurodegenerative conditions characterized by the
accumulation of protease-resistant forms of the prion protein (PrP), termed PrPres, in the brain. …
accumulation of protease-resistant forms of the prion protein (PrP), termed PrPres, in the brain. …
Polymer-bound camptothecin: initial biodistribution and antitumour activity studies
…, E Pesenti, M Gigli, F Angelucci, A Suarato - Journal of controlled …, 2000 - Elsevier
Camptothecin (CPT) is a potent, antitumour drug acting mainly through inhibition of
topoisomerase I during the S-phase of the cell cycle. Despite its impressive antitumour activity, …
topoisomerase I during the S-phase of the cell cycle. Despite its impressive antitumour activity, …
Circular dichroism studies on anthracycline antitumor compounds. Relationship between the molecular structure and the spectroscopic data
MML Fiallo, H Tayeb, A Suarato… - Journal of …, 1998 - Elsevier
The band assignment of the circular dichroism (CD) spectra of anthracyclines can provide
us with the tools to study the interaction of these molecules with biomolecules, such as DNA …
us with the tools to study the interaction of these molecules with biomolecules, such as DNA …
Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides
…, T Peterson, RA Conradi, PS Burton, A Suarato… - Drug metabolism and …, 1999 - ASPET
The mechanism of sulfonamide cleavage of PNU-109112, a potent HIV-1 protease inhibitor,
by glutathione-S-transferase (GST) was investigated in the presence of reduced GSH. GST-…
by glutathione-S-transferase (GST) was investigated in the presence of reduced GSH. GST-…
[PDF][PDF] Novel anthracycline analogs
…, D Ballinari, L Capolongo, A Suarato… - Cancer treatment …, 1990 - academia.edu
As is true also for other anticancer agents, the emergence of multidrug resistance (mdr) after
treatment with anthracyclines is a well documented phenomenon, and is recognized as …
treatment with anthracyclines is a well documented phenomenon, and is recognized as …
Camptothecin Poly[N-(2-Hydroxypropyl) Methacrylamide] Copolymers in Antitopoisomerase-I Tumor Therapy: Intratumor Release and Antitumor Efficacy
…, R d'Argy, A Fiorino, E Pesenti, A Suarato… - Molecular cancer …, 2003 - AACR
Soluble copolymers of camptothecin (CPT), based on poly[N-(2-hydroxypropyl)
methacrylamide] (pHPMA), were obtained by conjugation through the degradable spacers -Gly-Phe-Leu-…
methacrylamide] (pHPMA), were obtained by conjugation through the degradable spacers -Gly-Phe-Leu-…
Influence of structural modifications at the 3'and 4'positions of doxorubicin on the drug ability to trap topoisomerase II and to overcome multidrug resistance.
…, M Binaschi, L Capolongo, M Grandi, A Suarato… - Molecular …, 1994 - ASPET
To better define the role of the amino sugar in the pharmacological and biochemical properties
of anthracyclines related to doxorubicin and daunorubicin, we have investigated the …
of anthracyclines related to doxorubicin and daunorubicin, we have investigated the …
In vivo anti-tumour activity of FCE 23762, a methoxymorpholinyl derivative of doxorubicin active on doxorubicin-resistant tumour cells
…, A Pastori, M Farao, A Bargiotti, A Suarato… - British journal of …, 1992 - nature.com
FCE 23762 is a new doxorubicin derivative obtained by appending a methoxymorpholinyl
group at position 3'of the sugar moiety. The compound is greater than 80 times more potent …
group at position 3'of the sugar moiety. The compound is greater than 80 times more potent …