Preclinical 1. Cisplatin is a co-ordination complex of a central platinum atom, two chlordies
and two ammonia molecules in the “cis” position. 2. A prime mechanism of inhibition of tumor …

In earlier studies, the nucleolar levels of protein A24 were found to be markedly decreased in
the nucleolar hypertrophy induced by thioacetamide or during liver regeneration (Ballal, NR…

Purpose Individuals with metastatic melanoma have a poor prognosis. Many human melanomas
are auxotrophic for arginine, and arginine is not an essential amino acid in humans. We …

… Prestayko Stanley T. Crooke Bristol Laboratories Bristol Laboratories Syracuse, New York
Syracuse, New … Prestayko, and Stanley T. Crooke 213 … Prestayko, and Stanley T. Crooke 249 …

Extraction of nucleolar RNA at 65 C results in the liberation from nucleolar 28 s RNA of a
hitherto undescribed low molecular weight RNA referred to as 8 s (28 s) RNA, as well as a …

… Crooke, ST, Comis, AL, Einhorn, LH, Strong, JE, Broughton, A., and Prestayko, AW Effects of
… 1., Einhorn, LH, Comis, AL, D'Aoust, JC, and Prestayko, AW The effects of prior exposure to …

Archie W. Prestayko, G. Robert Klomp, David J. Schmoll, and Harris Busch* abstract:
Proteins have been isolated from Novikoff hepatoma polyribosomes, ribosomal subunits, and …

Jonathan A. Pachter,*-* 1***** Cheng-Hsiung Huang, Virgil H. DuVernay, Jr., Archie W.
Prestayko, 8 and StanleyT. Crooke8 abstract: Interactions involved in the binding of the an-…

Nucleolar 4 to 6 S RNA of Novikoff hepatoma ascites cells was fractionated by exclusion
chromatography on Sephadex G-100. Three peaks of RNA were separated: I, a fraction that …

The anthracyclines studied may be divided into two classes on the basis of their effects on
DNA and RNA syntheses. Class I anthracyclines-adriamycin, carminomycin, and pyrromycin-…