Translation of pre-clinical studies into successful clinical trials for Alzheimer's disease: what are the roadblocks and how can they be overcome?
Preclinical studies are essential for translation to disease treatments and effective use in
clinical practice. An undue emphasis on single approaches to Alzheimer’s disease (AD) …
clinical practice. An undue emphasis on single approaches to Alzheimer’s disease (AD) …
Electrophysiological properties of axons in mice lacking neurofilament subunit genes: disparity between conduction velocity and axon diameter in absence of NF-H
Neurofilament proteins (NFs) are made by co-polymerization of three intermediate filament
proteins, NF-L, NF-M and NF-H and constitute the most abundant cytoskeletal element in …
proteins, NF-L, NF-M and NF-H and constitute the most abundant cytoskeletal element in …
Electrochemical investigations of the interaction of C-reactive protein (CRP) with a CRP antibody chemically immobilized on a gold surface
H Hennessey, N Afara, S Omanovic, AL Padjen - Analytica chimica acta, 2009 - Elsevier
A possibility of using a range of dc and ac electrochemical techniques to probe associative
interactions of C-reactive protein (CRP) with CRP antibody (aCRP) immobilized on a gold …
interactions of C-reactive protein (CRP) with CRP antibody (aCRP) immobilized on a gold …
Axonal transport of organelles visualized by light microscopy: cinemicrographic and computer analysis
DS Forman, AL Padjen, GR Siggins - Brain research, 1977 - Elsevier
Rapid movements of intra-axonal organelles in acutely isolated single myelinated fibers
from bullfrog sciatic nerve were visualized by dark-field microscopy. The movements were …
from bullfrog sciatic nerve were visualized by dark-field microscopy. The movements were …
Altered ionic conductances in axons of transgenic mouse expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis
Neurofilaments (NFs; made by copolymerization of three intermediate filament proteins NF-L,
NF-M, and NF-H, for light, medium, and heavy) constitute the most abundant cytoskeletal …
NF-M, and NF-H, for light, medium, and heavy) constitute the most abundant cytoskeletal …
[PDF][PDF] Acetylcholine and slow synaptic inhibition in frog sympathetic ganglion cells
FF Weight, A Padjen - Brain Research, 1973 - academia.edu
The slow inhibitory postsynaptic potential (slow IPSP) in sympathetic ganglion cells has certain
unique electrophysiological properties a, 4. The frog sympathetic ganglion is particularly …
unique electrophysiological properties a, 4. The frog sympathetic ganglion is particularly …
Effect of temperature on the rapid retrograde transport of microscopically visible intra-axonal organelles
DS Forman, AL Padjen, GR Siggins - Brain research, 1977 - Elsevier
The effects of temperature on the retrograde axonal transport of microscopically visible intra-axonal
organelles was studied in acutely isolated myelinated axons from bullfrog sciatic …
organelles was studied in acutely isolated myelinated axons from bullfrog sciatic …
[HTML][HTML] Intra-axonal recording from large sensory myelinated axons: demonstration of impaired membrane conductances in early experimental diabetes
J Kriz, AL Padjen - Diabetologia, 2003 - Springer
Aim/hypothesis Diabetic neuropathy is accompanied by a range of positive (paresthaesia,
dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms …
dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms …
Taurine: sodium-dependent, high-affinity transport into rat brain synaptosomes
RE HRUSKA, A PADJEN, R BRESSLER… - Molecular …, 1978 - ASPET
Sodium-dependent transport of taurine into rat brain synaptosomes was studied using [ 3 H]taurine
of high specific activity (2.8 Ci/mmole). At 2.8 µM [ 3 H]taurine, 57% of the total …
of high specific activity (2.8 Ci/mmole). At 2.8 µM [ 3 H]taurine, 57% of the total …
Actions of acidic amino acids on the excitability of medial hypothalamic neurons in the rat
E Arnauld, BS Layton, AL Padjen, LP Renaud - Neuroendocrinology, 1983 - karger.com
Systemic administration of acidic amino acids produces selective neurotoxic effects on
neurons in the arcuate nucleus. However, little is known on the comparative or topographical …
neurons in the arcuate nucleus. However, little is known on the comparative or topographical …