Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
A Girnita, L Girnita, F Prete, A Bartolazzi, O Larsson… - Cancer research, 2004 - AACR
The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth,
and survival of malignant cells, and has emerged as a general and promising target for …
and survival of malignant cells, and has emerged as a general and promising target for …
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
L Girnita, A Girnita, O Larsson - Proceedings of the National …, 2003 - National Acad Sciences
Recently, p53 was demonstrated to affect the expression of the insulin-like growth factor 1
receptor (IGF-1R), a receptor tyrosine kinase that plays a crucial role in growth and survival of …
receptor (IGF-1R), a receptor tyrosine kinase that plays a crucial role in growth and survival of …
[HTML][HTML] Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation
L Girnita, C Worrall, SI Takahashi, S Seregard… - Cellular and molecular …, 2014 - Springer
The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …
and progression of cancer; however, therapeutics targeting it have had disappointing results …
The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol …
D Vasilcanu, A Girnita, L Girnita, R Vasilcanu… - Oncogene, 2004 - nature.com
The insulin-like growth factor-1 receptor (IGF-1R) is crucial for many functions in neoplastic
cells, for example, antiapoptosis. Recently, we demonstrated that the cyclolignan PPP …
cells, for example, antiapoptosis. Recently, we demonstrated that the cyclolignan PPP …
[HTML][HTML] β-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
L Girnita, SK Shenoy, B Sehat, R Vasilcanu… - Journal of Biological …, 2005 - ASBMB
The insulin-like growth factor-1 receptor (IGF-1R) plays important roles in physiological
growth and aging as well as promoting several crucial functions in cancer cells. However, the …
growth and aging as well as promoting several crucial functions in cancer cells. However, the …
[HTML][HTML] β-Arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression
L Girnita, SK Shenoy, B Sehat, R Vasilcanu… - Journal of Biological …, 2007 - ASBMB
β-Arrestin1, which regulates many aspects of seven transmembrane receptor (7TMR) biology,
has also been shown to serve as an adaptor, which brings Mdm2, an E3 ubiquitin ligase …
has also been shown to serve as an adaptor, which brings Mdm2, an E3 ubiquitin ligase …
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor
…, S Seregard, A Girnita, L Girnita - Proceedings of the …, 2012 - National Acad Sciences
β-Arrestins are multifunctional proteins that play central roles in G protein-coupled receptor (GPCR)
trafficking and signaling. β-Arrestin1 is also recruited to the insulin-like growth factor-…
trafficking and signaling. β-Arrestin1 is also recruited to the insulin-like growth factor-…
[HTML][HTML] Targeting the IGF-1R: the tale of the tortoise and the hare
The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and maintenance of cancer. Since the first links between growth factor receptors and …
and maintenance of cancer. Since the first links between growth factor receptors and …
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
A Girnita, C All-Ericsson, MA Economou… - Clinical cancer research …, 2006 - AACR
PURPOSE: Uveal melanoma has a high mortality rate due to a high incidence of metastasis
(up to 50%), which preferentially occurs in the liver. Conventional chemotherapy, being the …
(up to 50%), which preferentially occurs in the liver. Conventional chemotherapy, being the …
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma
S Yin, A Girnita, T Strömberg, Z Khan… - Neuro …, 2010 - academic.oup.com
Glioblastoma (GB) is the most common malignant brain tumor in adults. It has limited
treatment opportunities and is almost exclusively fatal. Owing to the central role the insulin-like …
treatment opportunities and is almost exclusively fatal. Owing to the central role the insulin-like …