User profiles for Adrian D. Sproul

Adrian Sproul

American Medical Response
Verified email at gmr.net
Cited by 158

Agonist-induced conformational changes in the extracellular domain of α7 nicotinic acetylcholine receptors

LK Lyford, AD Sproul, D Eddins, JT McLaughlin… - Molecular …, 2003 - ASPET
The molecular mechanisms that couple agonist binding to the gating of Cys-loop ionotropic
receptors are not well understood. The crystal structure of the acetylcholine (ACh) binding …

Role of the outer β-sheet in divalent cation modulation of α7 nicotinic receptors

JT McLaughlin, J Fu, AD Sproul, RL Rosenberg - Molecular pharmacology, 2006 - ASPET
α-7 Nicotinic acetylcholine receptors (AChRs) exhibit a positive modulation by divalent cations
similar to that observed in other AChRs. In the chick α7 AChR, this modulation involves a …

Glutamate 172, essential for modulation of L247T α7 ACh receptors by Ca2+, lines the extracellular vestibule

D Eddins, AD Sproul, LK Lyford… - … of Physiology-Cell …, 2002 - journals.physiology.org
Neuronal α 7 nicotinic ACh receptors (nAChRs) are permeable to and modulated by Ca 2+ ,
Ba 2+ , and Sr 2+ . These permeant divalent cations interact with slowly desensitizing L 247 …

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer

D Sproul, C Nestor, J Culley… - Proceedings of the …, 2011 - National Acad Sciences
Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this
mechanism to contribute to tumor development depends on whether the genes affected are …

[BOOK][B] Structures and Properties of Some Iron Triad Complexes: Iron (iii) Halide and Nickel (ii) Aquo Halide Complexes; Nickel (ii) and Nickel (iv) Pyridine Dioxime …

GD Sproul - 1971 - search.proquest.com
The number and arrangement of halide ligands coordinated to a transition metal in a complex
anion is often surprisingly dependent on the nature of cationic ions present. For example …

N-methyl-d-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct

A Sproul, SL Steele, TL Thai, SP Yu… - American Journal …, 2011 - journals.physiology.org
N-methyl-d-aspartate receptors (NMDARs) are Ca 2+ -permeable, ligand-gated, nonselective
cation channels that function as neuronal synaptic receptors but which are also expressed …

Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats

L Cui, J Jiang, L Wei, X Zhou, JL Fraser, BJ Snider… - Stem …, 2008 - academic.oup.com
… (D): Quantification of sciatic nerve diameter at the proximal stump site 1 and 3 months after
… The authors thank Adrian D. Sproul for his assistance in editing the manuscript. LC and JJ …

Critical Roles of the Na+/K+-ATPase in Apoptosis and CNS Diseases

A Sproul, X Zhou, SP Yu - Brain Hypoxia and Ischemia: with Special …, 2009 - Springer
The Na + /K + -ATPase is a transmembrane protein that serves as the primary electrogenic
ion transporter in the plasma membrane of all mammalian cells. In addition to this critical …

[HTML][HTML] Observations of the total solar eclipse of September 10, 1923, by the Sproul Observatory

JA Miller, RW Marriott - Sproul Observatory publications; no. 7 …, 1925 - adsabs.harvard.edu
Sproul negatives, there is a series of six additional fainter arches similar in shape and above
… on the arches as measured in inches on the Sproul and Douglas plates respectively. The …

Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic …

…, PV Johnston, JA Brinker, E Breton, J Davis-Sproul… - Jama, 2012 - jamanetwork.com
Context Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic
cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, …