Rare neglected diseases may be neglected but are hardly rare, affecting hundreds of millions
of people around the world. Here, we present a hit identification approach using AtomNet, …

Membrane transporters are key determinants of therapeutic outcomes. They regulate systemic
and cellular drug levels influencing efficacy as well as toxicities. Here we report a unique …

Species differences in renal drug transporters continue to plague drug development with
animal models failing to adequately predict renal drug toxicity. For example, adefovir, a renally …

Activating mutations in FLT3 occur in~ 30% of adult acute myeloid leukemia, primarily
consisting of internal tandem duplication (ITD) mutations (~ 25%) and point mutations in the …

Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of
structurally diverse endogenous compounds and xenobiotics. Here we identified competitive and …

The human solute carrier 22A (SLC22A) family consists of 23 members, representing one of
the largest families in the human SLC superfamily. Despite their pharmacological and …

Acute myeloid leukemia (AML) is a clinically heterogeneous disease, with a 5-year disease-free
survival (DFS) ranging from under 10% to over 70% for distinct groups of patients. At our …

Variation in steroid hormone levels has wide implications for health and disease. The genes
encoding the proteins involved in steroid disposition represent key determinants of …

Capping is a mechanical defect in tablet formulation and manufacture. Understanding what
influences tablet capping in terms of process variables and formulation properties and …

Human OAT1 and OAT3 play major roles in renal drug elimination and drug-drug interactions.
However, there is little information on the interactions of drug metabolites with transporters…