T-type calcium channels are essential contributors to the transmission of nociceptive signals
in the primary afferent pain pathway. Here, we show that T-type calcium channels are …

Epithelial sodium channels (ENaCs) perform diverse physiological roles by mediating Na +
absorption across epithelial surfaces throughout the body. Excessive Na + absorption in …

In rat hepatic C9 cells, angiotensin II (Ang II)-induced activation of angiotensin type 1 (AT 1 )
receptors (AT 1 -Rs) stimulates extracellular signal-regulated kinase (ERK) 1/2 …

It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the
plasma membrane, but the cellular mechanism by which this occurs has remained unclear. …

In C9 cells, LPA (lysophosphatidic acid) induced inositol phosphate production, increased
intracellular calcium concentration and inhibited adenylate cyclase activity. These responses …

Many epithelia, including the superficial epithelia of the airways, are thought to secrete “volume
sensors,” which regulate the volume of the mucosal lining fluid. The epithelial Na + …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) that prevent its proper folding and trafficking to the apical membrane of epithelial …

Peripheral nerve injury and tissue inflammation result in upregulation of the deubiquitinase
USP5, thus causing a dysregulation of T-type calcium channel activity and increased pain …

Pain-sensing sensory neurons of the dorsal root ganglion (DRG) can become sensitized or
hyperexcitable in response to surgically induced peripheral tissue injury. We investigated the …

Cav3.2 channels play an important role in the afferent nociceptive pathway, which is
responsible for both physiological and pathological pain transmission. Cav3.2 channels are …