NCX3 regulates mitochondrial Ca2+ handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death
…, A Secondo, F Boscia, A Esposito… - Journal of cell …, 2013 - journals.biologists.com
The mitochondrial influx and efflux of Ca 2+ play a relevant role in cytosolic and mitochondrial
Ca 2+ homeostasis, and contribute to the regulation of mitochondrial functions in neurons. …
Ca 2+ homeostasis, and contribute to the regulation of mitochondrial functions in neurons. …
[HTML][HTML] MicroRNA-103-1 selectively downregulates brain NCX1 and its inhibition by anti-miRNA ameliorates stroke damage and neurological deficits
…, P Cerullo, N Guida, O Cuomo, A Esposito… - Molecular Therapy, 2014 - cell.com
Na + /Ca2+ exchanger (NCX) is a plasma membrane transporter that, by regulating Ca2+ and
Na + homeostasis, contributes to brain stroke damage. The objectives of this study were to …
Na + homeostasis, contributes to brain stroke damage. The objectives of this study were to …
A new concept: Aβ1–42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death
…, C D'Avanzo, M Cantile, A Esposito… - Journal of …, 2012 - Soc Neuroscience
Although the amyloid-β 1–42 (Aβ 1–42 ) peptide involved in Alzheimer's disease is known
to cause a dysregulation of intracellular Ca 2+ homeostasis, its molecular mechanisms still …
to cause a dysregulation of intracellular Ca 2+ homeostasis, its molecular mechanisms still …
[HTML][HTML] ApoSOD1 lacking dismutase activity neuroprotects motor neurons exposed to beta-methylamino-L-alanine through the Ca2+/Akt/ERK1/2 prosurvival pathway
…, A Secondo, V Tedeschi, A Esposito… - Cell Death & …, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS) is a severe human adult-onset neurodegenerative
disease affecting lower and upper motor neurons. In> 20% of cases, the familial form of ALS is …
disease affecting lower and upper motor neurons. In> 20% of cases, the familial form of ALS is …
[HTML][HTML] Polychlorinated biphenyls induce mitochondrial dysfunction in SH-SY5Y neuroblastoma cells
Chronic exposure to polychlorinated biphenyls (PCBs), ubiquitous environmental contaminants,
can adversely affect the development and function of the nervous system. Here we …
can adversely affect the development and function of the nervous system. Here we …
[HTML][HTML] Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt …
A Secondo, A Esposito, R Sirabella, F Boscia… - Journal of Biological …, 2015 - ASBMB
NGF induces neuronal differentiation by modulating [Ca 2+ ] i . However, the role of the three
isoforms of the main Ca 2+ -extruding system, the Na + /Ca 2+ exchanger (NCX), in NGF-…
isoforms of the main Ca 2+ -extruding system, the Na + /Ca 2+ exchanger (NCX), in NGF-…
Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl) amino]-n-[[(2, 4-dimethylbenzyl)-amino] iminomethyl]-pyrazinecarboxamide …
…, P Ambrosino, P Lippiello, A Esposito… - … of Pharmacology and …, 2009 - ASPET
With the help of single-cell microflorimetry, 45 Ca 2+ radiotracer fluxes, and patch-clamp in
whole-cell configuration, we examined the effect of the amiloride derivative 3-amino-6-chloro-…
whole-cell configuration, we examined the effect of the amiloride derivative 3-amino-6-chloro-…
Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells
A Del Viscovo, A Secondo, A Esposito… - American Journal …, 2012 - journals.physiology.org
The role of 3,5,3′-triiodo-l-thyronine (T3) and its metabolite 3,5-diiodo-l-thyronine (T2) in
modulating the intracellular Ca 2+ concentration ([Ca 2+ ] i ) and endogenous nitric oxide (NO) …
modulating the intracellular Ca 2+ concentration ([Ca 2+ ] i ) and endogenous nitric oxide (NO) …
Pharmacological Characterization of the Newly Synthesized 5-Amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide Hydrochloride (BED) as a Potent NCX3 Inhibitor That …
…, M Cantile, O Cuomo, A Esposito… - ACS Chemical …, 2015 - ACS Publications
The Na + /Ca 2+ exchanger (NCX), a 10-transmembrane domain protein mainly involved in
the regulation of intracellular Ca 2+ homeostasis, plays a crucial role in cerebral ischemia. In …
the regulation of intracellular Ca 2+ homeostasis, plays a crucial role in cerebral ischemia. In …
[HTML][HTML] Na+/Ca2+ exchanger 1 on nuclear envelope controls PTEN/Akt pathway via nucleoplasmic Ca2+ regulation during neuronal differentiation
A Secondo, A Esposito, T Petrozziello, F Boscia… - Cell Death …, 2018 - nature.com
Nuclear envelope (NE) is a Ca 2+ -storing organelle controlling neuronal differentiation
through nuclear Ca 2+ concentrations ([Ca 2+ ] n ). However, how [Ca 2+ ] n regulates this …
through nuclear Ca 2+ concentrations ([Ca 2+ ] n ). However, how [Ca 2+ ] n regulates this …