Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular …

PE Chen, MT Geballe, PJ Stansfeld, AR Johnston… - Molecular …, 2005 - ASPET
We have used site-directed mutagenesis of amino acids located within the S1 and S2 ligand
binding domains of the NR2A N-methyl-d-aspartate (NMDA) receptor subunit to explore the …

Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie‐infected murine hippocampus

…, WG Halliday, J Bell, AR Johnston… - Neuropathology and …, 2000 - Wiley Online Library
Numbers of neurones, synapses and axon terminals were quantified in a murine scrapie
model with severe hippocampal pyramidal cell loss, in which definite clinical scrapie is evident …

Synthetic approaches for noncentrosymmetric molybdates

DJ Hubbard, AR Johnston, HS Casalongue… - Inorganic …, 2008 - ACS Publications
The use of second-order Jahn−Teller active Mo VI centers and chiral organic amines is
discussed as an approach to crystallographic noncentrosymmetry. Several series of reactions, …

Role of the flocculus in mediating vestibular nucleus neuron plasticity during vestibular compensation in the rat

AR Johnston, JR Seckl, MB Dutia - The Journal of physiology, 2002 - Wiley Online Library
We investigated the role of the cerebellar flocculus in mediating the adaptive changes that
occur in the intrinsic properties of brainstem medial vestibular nucleus (MVN) neurons during …

Development of action potentials and apamin-sensitive after-potentials in mouse vestibular nucleus neurones

MB Dutia, AR Johnston - Experimental brain research, 1998 - Springer
The postnatal maturation of medial vestibular nucleus (MVN) neurones was examined in
slices of the dorsal brainstem prepared from balb/c mice at specific stages during the first …

Synaptic plasticity in the CA1 area of the hippocampus of scrapie-infected mice

AR Johnston, JR Fraser, M Jeffrey, N MacLeod - Neurobiology of disease, 1998 - Elsevier
Using conventionalin vitroextracellular field potential recordings we have investigated both
short- and long-term synaptic plasticity in the hippocampal CA1 area of mice infected with …

Scrapie infection alters the membrane and synaptic properties of mouse hippocampal CA1 pyramidal neurones.

AR Johnston, C Black, J Fraser… - The Journal of …, 1997 - Wiley Online Library
1. Electrophysiological recordings using conventional intracellular and extracellular techniques
were made from the CA1 region of the hippocampus of ME7 scrapie‐infected mice in a …

Composition space analysis of templated molybdates

JH Nelson, AR Johnston, AN Sarjeant, AJ Norquist - Solid state sciences, 2007 - Elsevier
A systematic investigation of the factors governing reaction product composition and three-dimensional
structure was conducted in the MoO 3 /H 2 N(CH 2 ) n NH 2 /H 2 O (n=3–7) …

Xenopus temporal retinal neurites collapse on contact with glial cells from caudal tectum in vitro

AR Johnston, DJ Gooday - Development, 1991 - journals.biologists.com
Nasal and temporal retinal neurites were confronted in culture with glial cells from the rostral
and caudal parts of the optic tectum and with glial cells from the diencephalon. Twenty of …

Alterations in potassium currents may trigger neurodegeneration in murine scrapie

AR Johnston, JR Fraser, M Jeffrey, N MacLeod - Experimental neurology, 1998 - Elsevier
Conventional electrophysiological intracellular recording techniques were used to test the
hypothesis that enhanced calcium entry via voltage-gated calcium channels or theN-methyl-d-…