Neurotransmitters, such as γ-aminobutyric acid, glutamate, acetyl choline, glycine and the
monoamines, facilitate the crosstalk within the central nervous system. The designated …

Creatine provides cells with high-energy phosphates for the rapid reconstitution of hydrolyzed
adenosine triphosphate. The eponymous creatine transporter (CRT1/SLC6A8) belongs to …

The transporters for serotonin (SERT), dopamine, and noradrenaline have a conserved
hydrophobic core but divergent N and C termini. The C terminus harbors the binding site for the …

The serotonin transporter (SERT) is a member of the SLC6 family of solute carriers. SERT
plays a crucial role in synaptic neurotransmission by retrieving released serotonin. The …

Diseases arising from misfolding of SLC6 transporters have been reported over recent years,
eg. folding-deficient mutants of the dopamine transporter and of the glycine transporter-2 …

Point mutations in the gene encoding the human dopamine transporter (hDAT, SLC6A3)
cause a syndrome of infantile/juvenile dystonia and parkinsonism. To unravel the molecular …

The serotonin transporter (SERT) maintains serotonergic neurotransmission via rapid reuptake
of serotonin from the synaptic cleft. SERT relies exclusively on the coat protein complex II …

Mutations in the C terminus of the serotonin transporter (SERT) disrupt folding and export
from the endoplasmic reticulum. Here we examined the hypothesis that a cytosolic heat shock …

The folding trajectory of solute carrier 6 (SLC6) family members is of interest because point
mutations result in misfolding and thus cause clinically relevant phenotypes in people. Here …

Folding-defective mutants of the human dopamine transporter (DAT) cause a syndrome of
infantile dystonia/parkinsonism. Here, we provide a proof-of-principle that the folding deficit is …