Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization

M Quik, Y Polonskaya, A Gillespie… - Journal of …, 2000 - Wiley Online Library
Nicotinic receptors are implicated in memory, learning, locomotor activity, and addiction.
Identification of the specific receptor subtypes that mediate these behaviors is essential for …

Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells

…, BGM Durie, GE Nedwin, A Gillespie… - … England Journal of …, 1987 - Mass Medical Soc
Myeloma cells destroy bone by producing an osteoclast-stimulating factor that has chemical
and biological characteristics similar to the bone-resorbing activity present in the …

Dual action of n-alcohols on neuronal nicotinic acetylcholine receptors

Y Zuo, GL Aistrup, W Marszalec, A Gillespie… - Molecular …, 2001 - ASPET
Alcohol is known to modulate the activity of a variety of neuroreceptors and ion channels.
Recently, neuronal nicotinic acetylcholine receptors (nnAChRs) have become a specific focus …

Characterization of the recombinant human neuronal nicotinic acetylcholine receptors α3β2 and α4β2 stably expressed in HEK293 cells

LE Chavez-Noriega, A Gillespie, KA Stauderman… - …, 2000 - Elsevier
HEK293 cells were stably transfected with the cDNAs encoding full-length human neuronal
nicotinic acetylcholine receptor (nAChR) subunit combinations α3β2 or α4β2. [ 3 H]-(±)…

Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations α2β4, α3β4 and α4β4 stably expressed in HEK293 cells

…, JH Crona, EC Johnson, KJ Elliott, A Gillespie… - … of Pharmacology and …, 1998 - ASPET
Human embryonic kidney (HEK293) cells were transfected with cDNA encoding the human
β4 neuronal nicotinic acetylcholine (ACh) receptor subunit in pairwise combination with …

The expression of neuronal voltage-dependent calcium channels in human cerebellum

…, R Beattie, PG Ince, PJ Shaw, SB Ellis, A Gillespie… - Molecular brain …, 1995 - Elsevier
Little is known about the comparative distribution of voltage-dependent calcium channel
subtypes in normal human brain. Previous studies in experimental animals have predominantly …

CHO cell production and sequence improvement in the 13C6FR1 anti-Ebola antibody

…, RH Clark, C Crowell, J Ennis, A Gillespie, R Gillespie… - MAbs, 2016 - Taylor & Francis
From March 2014 through February 2015, the Ebola virus spread rapidly in West Africa,
resulting in almost 30,000 infections and approximately 10,000 deaths. With no approved …

Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH‐SY5Y neuroblastoma cells

U Warpman, L Friberg, A Gillespie… - Journal of …, 1998 - Wiley Online Library
The present study further investigated whether nicotinic acetylcholine receptor (nAChR)
subtypes differ in their ability to up‐regulate following chronic exposure to nicotinic agonists. …

The Development of a Novel Aflibercept Formulation for Ocular Delivery

JA Floyd, AJ Gillespie, NS Nightlinger, C Siska… - Journal of …, 2024 - Elsevier
Aflibercept is a recombinant fusion protein that is commercially available for several ocular
diseases impacting millions of people worldwide. Here, we use a case study approach to …

[HTML][HTML] Framework mutations of the 10-1074 bnAb increase conformational stability, manufacturability, and stability while preserving full neutralization activity

…, Y Brodsky, R Clark, JA Floyd, A Gillespie… - Journal of …, 2020 - Elsevier
The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated
IgG1 being developed for prophylaxis in sub-Saharan Africa. A series of algorithms were …