Herein we report that the novel HIV-inactivating protein cyanovirin-N (CV-N) targets specific,
N-linked high-mannose oligosaccharides found on the viral envelope of HIV-1. First, we …

The virucidal protein cyanovirin-N (CV-N) mediates its highly potent anti-human immunodeficiency
virus activity, at least in part, through interactions with the viral envelope glycoprotein …

One of the functions of N-linked glycans of viral glycoproteins is protecting otherwise accessible
neutralization epitopes of the viral envelope from neutralizing antibodies. The aim of the …

Due to the biological significance of the carbohydrate component of the human
immunodeficiency virus type 1 (HIV-1) glycoproteins in viral pathogenesis, the glycosylation step …

DNA encoding HIV-1 env is a poorly efficient B-cell immunogen and one probable explanation
is that the numerous gp120 N-linked glycans gp120 may interfere with B-cell epitope …

Site-directed mutagenesis was used to study the biological significance of a disulphide
bridge and two N-linked oligosaccharides in the CD4-binding region of the envelope …

In the present study we investigated to what extent the peripheral carbohydrate structure of
N-linked glycans influences the antigenic properties of human immunodeficiency virus type 1 …

Limited data are available on the genotypic and phenotypic resistance profile of the α-(1-2)mannose
oligomer-specific prokaryotic lectin cyanovirin (CV-N). Therefore, a more systematic …

The V3 region of the human immunodeficiency virus type 1 envelope protein gp120
constitutes a potential neutralization target, but the oligosaccharide of one conserved N-…

… Indeed, Bolmstedt and colleagues reported that immunization of mice with HIV-1 gp120
lacking the Asn336 glycosylation signal (mutant 306NNA308) in the V3 loop (the gp120 amino …