Cloning and characterization of two human polyspecific organic cation transporters

…, S Quester, C Baumann, F Lang, AE Busch… - DNA and cell …, 1997 - liebertpub.com
Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal
proximal tubules and hepatocytes and mediates electrogenic uptake of organic cations with …

Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine

AE Busch, U Karbach, D Miska, V Gorboulev… - Molecular …, 1998 - ASPET
Recently, we cloned the human cation transporter hOCT2, a member of a new family of
polyspecific transporters from kidney, and demonstrated electrogenic uptake of …

[HTML][HTML] Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity

…, G Seebohm, C Derst, AD Wei, AE Busch… - Journal of Biological …, 2000 - ASBMB
We have isolated KCNQ5, a novel human member of the KCNQ potassium channel gene
family that is differentially expressed in subregions of the brain and in skeletal muscle. When …

Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular …

RF Bosch, R Gaspo, AE Busch, HJ Lang… - Cardiovascular …, 1998 - academic.oup.com
Objectives: The slow component of the delayed rectifier K + current (I Ks ) is believed to be
important in cardiac repolarization, and may be a potential target for antiarrhythmic drugs, but …

DCPIB is a novel selective blocker of ICl,swell and prevents swelling‐induced shortening of guinea‐pig atrial action potential duration

…, B Nilius, A Brüggemann, AE Busch… - British journal of …, 2001 - Wiley Online Library
We identified the ethacrynic‐acid derivative DCPIB as a potent inhibitor of I Cl,swell , which
blocks native I Cl,swell of calf bovine pulmonary artery endothelial (CPAE) cells with an IC 50 …

[HTML][HTML] Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1

AE Busch, S Quester, JC Ulzheimer… - Journal of Biological …, 1996 - ASBMB
The previously cloned rat cation transporter rOCT1 detected in renal proximal tubules and
hepatocytes (Gründemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M., and Koepsell, H. (…

Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces ICa,Land Itoin rapid atrial pacing in rabbits

…, S Wöhrl, K Steinmeyer, H Haase, AE Busch… - Journal of the American …, 2003 - jacc.org
Objectives : The purpose of the study was to characterize the ionic and molecular mechanisms
in the very early phases of electrical remodeling in a rabbit model of rapid atrial pacing (…

Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling

…, R Savai, HA Ghofrani, F Grimminger, AE Busch… - Circulation, 2008 - Am Heart Assoc
Background— Inhibition of tyrosine kinases, including platelet-derived growth factor receptor,
can reduce pulmonary arterial pressure in experimental and clinical pulmonary …

[HTML][HTML] Obligatory amino acid exchange via systems bo,+-like and y+ L-like: a tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino …

…, F Lang, JL Gelpí, X Testar, AE Busch… - Journal of Biological …, 1996 - ASBMB
Mutations in the rBAT gene cause type I cystinuria, a common inherited aminoaciduria of
cystine and dibasic amino acids due to their defective renal and intestinal reabsorption (…

Characterization of TASK‐4, a novel member of the pH‐sensitive, two‐pore domain potassium channel family

…, J Gassenhuber, A Brüggemann, AE Busch… - FEBS …, 2001 - Wiley Online Library
We report the primary sequence of TASK‐4, a novel member of the acid‐sensitive subfamily
of tandem pore K + channels. TASK‐4 transcripts are widely expressed in humans, with …