Cytochrome P450 2C19 681G> A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous …
…, W Hochholzer, MF Fromm, LE Chialda, A Pahl… - Journal of the American …, 2008 - jacc.org
Objectives : We investigated whether the loss of function CYP2C19 681G>A *2 polymorphism
is associated with high (>14%) residual platelet aggregation (RPA) on clopidogrel and …
is associated with high (>14%) residual platelet aggregation (RPA) on clopidogrel and …
Importance of Kupffer cells for T-cell-dependent liver injury in mice
J Schümann, D Wolf, A Pahl, K Brune… - The American journal of …, 2000 - Elsevier
T cells seem to be responsible for liver damage in any type of acute hepatitis. Nevertheless,
the importance of Kupffer cells (KCs) for T-cell-dependent liver failure is unclear. Here we …
the importance of Kupffer cells (KCs) for T-cell-dependent liver failure is unclear. Here we …
TP53 loss creates therapeutic vulnerability in colorectal cancer
…, G Lopez-Berestein, PH Rao, DM Maru, A Pahl… - Nature, 2015 - nature.com
TP53, a well-known tumour suppressor gene that encodes p53, is frequently inactivated by
mutation or deletion in most human tumours 1 , 2 . A tremendous effort has been made to …
mutation or deletion in most human tumours 1 , 2 . A tremendous effort has been made to …
[HTML][HTML] Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
…, B Layh, C Heindl, M Hamza, A Pahl… - The Journal of …, 2005 - Am Soc Clin Investig
Blockade of prostaglandin (PG) production by COX inhibitors is the treatment of choice for
inflammatory pain but is also prone to severe side effects. Identification of signaling elements …
inflammatory pain but is also prone to severe side effects. Identification of signaling elements …
Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells
…, S Prechtl, M Röllinghoff, E Schmitt, A Pahl… - The Journal of …, 2000 - rupress.org
Interferon (IFN) regulatory factor (IRF)-2 was originally described as an antagonist of IRF-1–mediated
transcriptional regulation of IFN-inducible genes. IRF-1 −/ − mice exhibit defective …
transcriptional regulation of IFN-inducible genes. IRF-1 −/ − mice exhibit defective …
Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury
K Schuh, A Pahl - Biochemical pharmacology, 2009 - Elsevier
The pathogenesis of chronic obstructive pulmonary disease (COPD) is characterized by
pulmonary inflammation associated with lung neutrophilia and elevated levels of pro-…
pulmonary inflammation associated with lung neutrophilia and elevated levels of pro-…
Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice
H Sann, J von Erichsen, M Hessmann, A Pahl… - Life sciences, 2013 - Elsevier
AIMS: Although acute dextran sodium sulphate (DSS)-induced colitis in mice is frequently
used as a preclinical model for testing drugs involved in inflammatory bowel disease (IBD), …
used as a preclinical model for testing drugs involved in inflammatory bowel disease (IBD), …
Quantitative Detection of Borrelia burgdorferi by Real-Time PCR
A Pahl, U Kühlbrandt, K Brune… - Journal of clinical …, 1999 - Am Soc Microbiol
Currently, no easy and reliable methods allowing for the quantification of Borrelia burgdorferi
in tissues of infected humans or animals are available. Due to the lack of suitable assays to …
in tissues of infected humans or animals are available. Due to the lack of suitable assays to …
Amanitins and their development as a payload for antibody-drug conjugates
A Pahl, C Lutz, T Hechler - Drug Discovery Today: Technologies, 2018 - Elsevier
Amanitin-based ADCs represent a new class of ADCs using a novel mode of action. This
payload introduces a novel mode of action into oncology therapy, the inhibition of RNA …
payload introduces a novel mode of action into oncology therapy, the inhibition of RNA …
Polymorphisms of TLR4: Rapid Genotyping and Reduced Response to Lipopolysaccharide of TLR4 Mutant Alleles
…, A Humeny, CM Becker, K Brune, A Pahl - Clinical …, 2002 - academic.oup.com
Background: Pathogen recognition receptors such as Toll-like receptors (TLRs), which
recognize pathogen-associated molecular patterns, lead to the activation of innate immunity. …
recognize pathogen-associated molecular patterns, lead to the activation of innate immunity. …